PMID- 29403725
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2095-1779 (Print)
IS  - 2214-0883 (Electronic)
IS  - 2214-0883 (Linking)
VI  - 2
IP  - 1
DP  - 2012 Feb
TI  - Determination of fluoroquinolones, sulfonamides, and tetracyclines multiresidues 
      simultaneously in porcine tissue by MSPD and HPLC-DAD.
PG  - 76-81
LID - 10.1016/j.jpha.2011.09.007 [doi]
AB  - An efficient method is provided to detect simultaneously some important 
      veterinary drugs from different classes in highly complex animal tissue matrix. 
      This method using matrix solid-phase dispersion (MSPD) and high performance 
      liquid chromatography (HPLC) with diode array detection (DAD) is developed to 
      effectively determine two fluoroquinolones (enoxacin and lomefloxacin), two 
      sulfonamides (sulfanilamide and sulfamethoxazole) and one tetracycline 
      (tetracycline) simultaneously in porcine tissues. In the process, MSPD 
      methodology was used to treat samples, washed by n-hexane to remove lipid, eluted 
      the analytes with acetonitrile-dichloromethane (1:1, v/v). Solvent acetonitrile 
      and solvent acetic acid (0.1%) were combined in a gradient. HPLC-DAD analysis of 
      the tissue samples was performed within 15 min at a flow rate of 1.0 mL/min. The 
      results showed that a recovery at 0.1, 0.5 and 1.0 mug/g fortification levels 
      ranged from 80.6% to 99.2% with satisfactory relative standard deviations (RSDs) 
      (below 6.1%, n=3) and the limits of quantitation (LOQ) ranged from 7 mug/kg to 
      34 mug/kg in porcine tissues. Utilization of the method in successfully 
      simultaneous analysis of porcine tissue incurred with veterinary drug 
      multiresidues is described.
FAU - Yu, Hu
AU  - Yu H
AD  - Chemistry Department of Science School, Xi'an Jiaotong University, Xi'an 710049, 
      China.
FAU - Mu, Hui
AU  - Mu H
AD  - Chemistry Department of Science School, Xi'an Jiaotong University, Xi'an 710049, 
      China.
FAU - Hu, Ying-Mei
AU  - Hu YM
AD  - Chemistry Department of Science School, Xi'an Jiaotong University, Xi'an 710049, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - China
TA  - J Pharm Anal
JT  - Journal of pharmaceutical analysis
JID - 101579451
PMC - PMC5760821
OTO - NOTNLM
OT  - Fluoroquinolones
OT  - High performance liquid chromatography
OT  - Matrix solid-phase dispersion
OT  - Multiresidues
OT  - Sulfonamides
OT  - Tetracyclines
EDAT- 2012/02/01 00:00
MHDA- 2012/02/01 00:01
PMCR- 2011/11/04
CRDT- 2018/02/07 06:00
PHST- 2011/07/16 00:00 [received]
PHST- 2011/09/09 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2012/02/01 00:00 [pubmed]
PHST- 2012/02/01 00:01 [medline]
PHST- 2011/11/04 00:00 [pmc-release]
AID - S2095-1779(11)00034-7 [pii]
AID - 10.1016/j.jpha.2011.09.007 [doi]
PST - ppublish
SO  - J Pharm Anal. 2012 Feb;2(1):76-81. doi: 10.1016/j.jpha.2011.09.007. Epub 2011 Nov 
      4.