PMID- 29403891
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2095-1779 (Print)
IS  - 2214-0883 (Electronic)
IS  - 2214-0883 (Linking)
VI  - 4
IP  - 4
DP  - 2014 Aug
TI  - Extraction and determination of trace amounts of chlorpromazine in biological 
      fluids using magnetic solid phase extraction followed by HPLC.
PG  - 279-285
LID - 10.1016/j.jpha.2014.03.003 [doi]
AB  - A simple, rapid and sensitive method termed as magnetic solid phase extraction 
      (MSPE) combined with high-performance liquid chromatography-ultraviolet detector 
      (HPLC-UV) has been proposed for the determination of trace amounts of 
      chlorpromazine (CPZ) in water, urine and plasma samples. The separation and 
      determination was performed on a C18 column under the optimal chromatographic 
      conditions. Several factors influencing the extraction efficiency of CPZ, such as 
      pH, surfactant and adsorbent amounts, ionic strength, extraction time, sample 
      volume and desorption conditions, were studied and optimized. Under the optimal 
      MSPE conditions, the extraction percentage of CPZ was 74%, 27% and 16% in water, 
      urine and plasma samples, respectively. The limits of detection (LODs) of the 
      proposed approach were 0.1, 5.0 and 10 ng/mL in water, urine and plasma samples, 
      respectively. The relative standard deviations (RSDs) based on five replicate 
      determinations at 10 ng/mL level of CPZ was 1.2%. Good linear behaviors over the 
      investigated concentration ranges (0.25-300 ng/mL) with good coefficient of 
      determination, R(2)>0.9998, were obtained. Good spike recoveries with relative 
      errors less than 9.0% were obtained when applying the proposed method to water, 
      urine and plasma samples.
FAU - Yamini, Yadollah
AU  - Yamini Y
AD  - Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, 
      Iran.
FAU - Faraji, Mohammad
AU  - Faraji M
AD  - Faculty of Food Industry and Agriculture, Department of Food Science & 
      Technology, Standard Research Institute (SRI), Karaj, P.O. Box 31745-139, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140313
PL  - China
TA  - J Pharm Anal
JT  - Journal of pharmaceutical analysis
JID - 101579451
PMC - PMC5761214
OTO - NOTNLM
OT  - Chlorpromazine
OT  - Magnetic solid phase extraction
OT  - Mixed-hemimicelles
EDAT- 2014/08/01 00:00
MHDA- 2014/08/01 00:01
PMCR- 2014/03/13
CRDT- 2018/02/07 06:00
PHST- 2014/01/05 00:00 [received]
PHST- 2014/02/18 00:00 [revised]
PHST- 2014/03/05 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2014/08/01 00:00 [pubmed]
PHST- 2014/08/01 00:01 [medline]
PHST- 2014/03/13 00:00 [pmc-release]
AID - S2095-1779(14)00011-2 [pii]
AID - 10.1016/j.jpha.2014.03.003 [doi]
PST - ppublish
SO  - J Pharm Anal. 2014 Aug;4(4):279-285. doi: 10.1016/j.jpha.2014.03.003. Epub 2014 
      Mar 13.