PMID- 29403946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2095-1779 (Print)
IS  - 2214-0883 (Electronic)
IS  - 2214-0883 (Linking)
VI  - 5
IP  - 5
DP  - 2015 Oct
TI  - Determination of atractylon in rat plasma by a GC-MS method and its application 
      to a pharmacokinetic study.
PG  - 327-331
LID - 10.1016/j.jpha.2015.03.002 [doi]
AB  - A sensitive and selective method based on gas chromatography hyphenated to mass 
      spectrometry (GC-MS) was developed and validated for the determination of 
      atractylon in rat plasma. Plasma samples were processed by liquid-liquid 
      extraction with ethyl acetate-n-hexane (1:1, v/v) using acetophenone as an 
      internal standard (IS). Analytes were determined in selective ion monitoring 
      (SIM) mode using target ions at m/z 108.1 for atractylon and m/z 105.1 for 
      acetophenone. The calibration curve was linear over the concentration range of 
      10-1000 ng/mL with lower limit of quantification of 10 ng/mL. The intra- and 
      inter-day precision variations were not more than 10.4% and 9.6%, respectively, 
      whilst accuracy values ranged from -6.5% to 4.9%. Extraction recovery of the 
      assay was satisfactory. This method was successfully applied to quantification 
      and pharmacokinetic study of atractylon in rat plasma after intragastric 
      administration of Atractylodis extract.
FAU - Yan, Han
AU  - Yan H
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
FAU - Sun, Yuanyuan
AU  - Sun Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
FAU - Ma, Yuying
AU  - Ma Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
FAU - Ji, Bin
AU  - Ji B
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
FAU - Hou, Xiaohong
AU  - Hou X
AD  - School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 
      Wenhua Road, Shenhe District, Shenyang 110016, China.
FAU - Yu, Zhiguo
AU  - Yu Z
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
FAU - Zhao, Yunli
AU  - Zhao Y
AD  - School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe 
      District, Shenyang 110016, China.
LA  - eng
PT  - Journal Article
DEP - 20150328
PL  - China
TA  - J Pharm Anal
JT  - Journal of pharmaceutical analysis
JID - 101579451
PMC - PMC5762239
OTO - NOTNLM
OT  - Atractylodis
OT  - Atractylon
OT  - GC-MS
OT  - Pharmacokinetics
OT  - Rat plasma
EDAT- 2015/10/01 00:00
MHDA- 2015/10/01 00:01
PMCR- 2015/03/28
CRDT- 2018/02/07 06:00
PHST- 2015/01/11 00:00 [received]
PHST- 2015/03/07 00:00 [revised]
PHST- 2015/03/20 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2015/10/01 00:00 [pubmed]
PHST- 2015/10/01 00:01 [medline]
PHST- 2015/03/28 00:00 [pmc-release]
AID - S2095-1779(15)00035-0 [pii]
AID - 10.1016/j.jpha.2015.03.002 [doi]
PST - ppublish
SO  - J Pharm Anal. 2015 Oct;5(5):327-331. doi: 10.1016/j.jpha.2015.03.002. Epub 2015 
      Mar 28.