PMID- 29405111
OWN - NLM
STAT- MEDLINE
DCOM- 20190710
LR  - 20190710
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 98
IP  - 4
DP  - 2018 Apr
TI  - Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a 
      Young Patient with the Acute Form Disease: Paracoccidioides brasiliensis or 
      Paracoccidioides lutzii?
PG  - 1082-1085
LID - 10.4269/ajtmh.17-0812 [doi]
AB  - Negative results in serological routine screening of patients with 
      microbiologically proven Paracoccidioidomycosis (PCM) are occasionally reported. 
      Failure in detecting anti-Paracoccidioides antibodies has been ascribed to 
      factors either related to serological techniques or to the status of the host 
      immune reactivity. Recently, this issue has been renewed by the recognition that 
      the Paracoccidioides genera comprises two species, lutzii and brasiliensis, which 
      have distinct antigenic profiles and, therefore, may elicit different host 
      antibody responses. We describe a patient with the acute form PCM due to 
      Paracoccidioides brasiliensis with negative results on two reference centers' 
      routine screening for P. brasiliensis antibodies, but positive results with 
      Paracoccidioides lutzii antigens. The present case report suggests that 
      antibodies elicited during P. brasiliensis infection recognize antigenic 
      fractions shared by both species, highlighting the difficulties in distinguishing 
      the two infections by means of the currently available routine serological 
      assays.
FAU - Buccheri, Renata
AU  - Buccheri R
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
AD  - Emilio Ribas Institute of Infectious Diseases, Sao Paulo, Brazil.
FAU - Morais, Vanessa Dos Santos
AU  - Morais VDS
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
FAU - Kamikawa, Camila Mika
AU  - Kamikawa CM
AD  - Immunology Center, Institute Adolfo Lutz, Sao Paulo, Brazil.
FAU - Vidal, Monica Scarpelli Martinelli
AU  - Vidal MSM
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
FAU - Naves, Gabriel
AU  - Naves G
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
FAU - Del Negro, Gilda Maria Barbaro
AU  - Del Negro GMB
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
FAU - Vicentini, Adriana Pardini
AU  - Vicentini AP
AD  - Immunology Center, Institute Adolfo Lutz, Sao Paulo, Brazil.
FAU - Benard, Gil
AU  - Benard G
AD  - Laboratory of Medical Investigation in Dermatology and Immunodeficiencies Unit 
      #56, Medical School and Tropical Medicine Institute, University of Sao Paulo 
      Medical School, Sao Paulo, Brazil.
AD  - Laboratory of Medical Investigation in Medical Mycology Unit #53, Medical School 
      and Tropical Medicine Institute, University of Sao Paulo Medical School, Sao 
      Paulo, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180201
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antibodies, Bacterial)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Antibodies, Bacterial/blood
MH  - Humans
MH  - Male
MH  - Paracoccidioides/immunology
MH  - Paracoccidioidomycosis/*diagnosis
MH  - Serologic Tests
PMC - PMC5928833
EDAT- 2018/02/07 06:00
MHDA- 2019/07/11 06:00
PMCR- 2019/04/01
CRDT- 2018/02/07 06:00
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/07/11 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - tpmd170812 [pii]
AID - 10.4269/ajtmh.17-0812 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2018 Apr;98(4):1082-1085. doi: 10.4269/ajtmh.17-0812. Epub 
      2018 Feb 1.