PMID- 29405727
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20181202
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 119
IP  - 1
DP  - 2018
TI  - Effect of quercetin on the brain-derived neurotrophic factor gene expression in 
      the rat brain.
PG  - 28-31
LID - 10.4149/BLL_2018_006 [doi]
AB  - INTRODUCTION: Quercetin is a ubiquitous flavonoid found in many plants. 
      Neuroprotective effects of quercetin have been shown in several in vitro and in 
      vivo studies, but its mechanism of action has not been fully defined yet. 
      Brain-derived neurotrophic factor (BDNF) is a fundamental neurotrophin with vital 
      functions in the survival of neuronal cells. In the present study, we aimed to 
      investigate the effects of quercetin on expression of BDNF mRNA in the 
      hippocampus of rat brain. METHODS: Male rats were daily gavaged with quercetin 
      (10, 20 or 50 mg/kg.bwt) for 30 days. Hippocampal levels of the BDNF transcripts 
      were assessed using quantitative (q) RT-PCR. RESULTS: Quercetin at doses of 20 
      and 50 mg/kg caused a significant increase in the mRNA expression of BDNF as 
      compared with the control group. Quercetin treatment at a dose of 10 mg/kg failed 
      to cause any significant changes in the levels of BDNF mRNA CONCLUSION: Our 
      findings suggest that the neuroprotective effects of quercetin may be at least 
      partly due to its inducing effects on the expression levels of the BDNF mRNA 
      (Fig. 1, Ref. 40).
FAU - Rahvar, M
AU  - Rahvar M
FAU - Owji, A A
AU  - Owji AA
FAU - Mashayekhi, F J
AU  - Mashayekhi FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (RNA, Messenger)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*drug effects/metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Neurons/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Quercetin/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - BDNF
OT  - hippocampus rat.
OT  - quercetin
EDAT- 2018/02/07 06:00
MHDA- 2018/06/02 06:00
CRDT- 2018/02/07 06:00
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
AID - 10.4149/BLL_2018_006 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2018;119(1):28-31. doi: 10.4149/BLL_2018_006.