PMID- 29406026
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20180307
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1076
DP  - 2018 Feb 15
TI  - Method development, matrix effect, and risk assessment of 49 multiclass 
      pesticides in kiwifruit using liquid chromatography coupled to tandem mass 
      spectrometry.
PG  - 130-138
LID - S1570-0232(17)32108-6 [pii]
LID - 10.1016/j.jchromb.2018.01.015 [doi]
AB  - In the present study, a liquid chromatography coupled with tandem mass 
      spectrometry (LC-MS/MS) method with a minimal matrix effect (ME) was developed 
      and validated for simultaneous determination of a diverse range of pesticides 
      (49) in kiwifruit. Samples extracted by the quick, easy, cheap, effective, 
      rugged, and safe (QuEChERS) citrate-buffered method were analyzed either without 
      purification or following purification (with primary secondary amine (PSA) or 
      PSA + graphitized carbon black (GCB)). With the addition of a clean-up step, the 
      suppression of the ME decreased, with a higher number of pesticides determined by 
      the application of PSA + GCB. The method exhibited good linearity with 
      coefficients of determination (R(2)) >/= 0.9972 and satisfactory recoveries 
      (70-120%) with a relative standard deviations (RSDs) <10%. The limits of 
      quantification (LOQ) were lower than the maximum residue limits (MRLs) set by the 
      Korean Ministry of Food and Drug Safety (MFDS) and the CODEX Alimentarius. The 
      developed method was applied to the real samples and the results indicated that 
      the quantitated levels of all pesticides, except for pyraclostrobin and 
      carbendazim, are lower than the MRLs set by the regulatory authorities. The 
      percentage of the acceptable daily intake was <20%, suggesting that there is no 
      risk associated with the intake of residual pesticides through kiwifruit.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kim, Yool-Ah
AU  - Kim YA
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, Gwangju 500-757, Republic of Korea.
FAU - Abd El-Aty, A M
AU  - Abd El-Aty AM
AD  - Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 
      12211 Giza, Egypt; Department of Veterinary Pharmacology and Toxicology, College 
      of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea. 
      Electronic address: amabdelaty@konkuk.ac.kr.
FAU - Rahman, Md Musfiqur
AU  - Rahman MM
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, Gwangju 500-757, Republic of Korea.
FAU - Jeong, Ji Hoon
AU  - Jeong JH
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea; Department of 
      Pharmacology, College of Medicine, Chung-Ang University, 221, Heuksuk-dong, 
      Dongjak-gu, Seoul 156-756, Republic of Korea.
FAU - Shin, Ho-Chul
AU  - Shin HC
AD  - Department of Veterinary Pharmacology and Toxicology, College of Veterinary 
      Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
FAU - Wang, Jing
AU  - Wang J
AD  - Key Laboratory for Agro-Products Quality and Safety, Institute of Quality 
      Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural 
      Sciences, Beijing 100081, China.
FAU - Shin, SungShik
AU  - Shin S
AD  - Laboratory of Parasitology, College of Veterinary Medicine, Chonnam National 
      University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
FAU - Shim, Jae-Han
AU  - Shim JH
AD  - Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, 
      Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic 
      address: jhshim@chonnam.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Pesticide Residues)
SB  - IM
MH  - Actinidia/*chemistry
MH  - Chromatography, Liquid/*methods
MH  - Food Safety
MH  - Fruit/*chemistry/standards
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Pesticide Residues/*analysis/standards
MH  - Reproducibility of Results
MH  - Republic of Korea
MH  - Risk Assessment
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Food safety
OT  - Kiwifruits
OT  - Liquid chromatography-tandem mass spectrometry
OT  - Matrix suppression effect
OT  - Simultaneous analysis
OT  - Validation
EDAT- 2018/02/07 06:00
MHDA- 2018/03/08 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/12/10 00:00 [received]
PHST- 2018/01/03 00:00 [revised]
PHST- 2018/01/15 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
AID - S1570-0232(17)32108-6 [pii]
AID - 10.1016/j.jchromb.2018.01.015 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 15;1076:130-138. doi: 
      10.1016/j.jchromb.2018.01.015.