PMID- 29406919
OWN - NLM
STAT- MEDLINE
DCOM- 20190524
LR  - 20190524
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 385
DP  - 2018 Feb 15
TI  - Correlation between serum uric acid and diabetic peripheral neuropathy in T2DM 
      patients.
PG  - 78-82
LID - S0022-510X(17)34475-1 [pii]
LID - 10.1016/j.jns.2017.11.034 [doi]
AB  - AIM: To investigate the correlation between serum uric acid (SUA) and diabetic 
      peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. METHODS: 
      Two hundred T2DM patients were divided into four groups at the cut-off points of 
      5, 7, and 9mg/dL of SUA levels. Nerve conduction studies (NCS), Semmes-Weinstein 
      monofilament testing (SWMT), and vibration perception threshold (VPT) tests were 
      performed on these patients. RESULTS: Significant differences in motor/sensory 
      nerve amplitude and conduction velocity (CV) parameters among different SUA level 
      groups were observed (all P<0.05). SUA levels were negatively correlated with the 
      means of motor/sensory nerve amplitude and CV (all P<0.05). Duration of T2DM 
      >10years, SUA >9mg/dL and total cholesterol (TC) >5.2mmol/L were found to be 
      significantly associated with DPN (all P<0.05). Receiver-operating characteristic 
      (ROC) analysis revealed that the cut-off points of T2DM duration combined with 
      SUA and TC were 9years, 7.8mg/dL, and 4.97mmol/L, respectively (AUC=0.65; 95% CI: 
      0.53-0.77; sensitivity, 70.6%; specificity, 65.2%, P=0.009). CONCLUSION: There is 
      a significant association between elevated SUA levels and DPN, and T2DM duration, 
      SUA, and TC may be valuable indicators to predict the occurrence of DPN in T2DM 
      patients.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Lin, Xiaopu
AU  - Lin X
AD  - Department of Huiqiao Building, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Xu, Lingling
AU  - Xu L
AD  - Department of Endocrinology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Zhao, Deqiang
AU  - Zhao D
AD  - Department of Huiqiao Building, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Luo, Zhiyin
AU  - Luo Z
AD  - Department of Huiqiao Building, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China.
FAU - Pan, Suyue
AU  - Pan S
AD  - Department of Neurology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510515, China. Electronic address: pansuyue82@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171128
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 268B43MJ25 (Uric Acid)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - J Neurol Sci. 2018 Jul 15;390:208. PMID: 29801889
MH  - Adult
MH  - Aged
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Diabetic Neuropathies/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Serum uric acid
OT  - Type 2 diabetes mellitus
EDAT- 2018/02/07 06:00
MHDA- 2019/05/28 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/08/16 00:00 [received]
PHST- 2017/11/05 00:00 [revised]
PHST- 2017/11/26 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/05/28 06:00 [medline]
AID - S0022-510X(17)34475-1 [pii]
AID - 10.1016/j.jns.2017.11.034 [doi]
PST - ppublish
SO  - J Neurol Sci. 2018 Feb 15;385:78-82. doi: 10.1016/j.jns.2017.11.034. Epub 2017 
      Nov 28.