PMID- 29406938 OWN - NLM STAT- MEDLINE DCOM- 20180830 LR - 20180830 IS - 1558-299X (Electronic) IS - 0095-4543 (Linking) VI - 45 IP - 1 DP - 2018 Mar TI - Metabolic Syndrome: Systems Thinking in Heart Disease. PG - 109-129 LID - S0095-4543(17)30130-6 [pii] LID - 10.1016/j.pop.2017.10.003 [doi] AB - Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors. MetS is associated with approximately 4-fold increase in the likelihood of developing type 2 diabetes mellitus (T2DM) and a 2-fold increase in the incidence of cardiovascular disease complications. MetS is a progressive, proinflammatory, prothrombotic condition that manifests itself along a broad spectrum of disease. It is associated with hypertension, obstructive sleep apnea, fatty liver disease, gout, and polycystic ovarian syndrome. Intervening in and reversing the pathologic process become more difficult as the disease progresses, highlighting the needs for increased individual and community surveillance and primary prevention. CI - Copyright (c) 2017 Elsevier Inc. All rights reserved. FAU - Dommermuth, Ron AU - Dommermuth R AD - Northwest Washington Family Medicine Residency, 2512 Wheaton Way, Suite B, Bremerton, WA 98310, USA. Electronic address: ronald.dommermuth@harrisonmedical.org. FAU - Ewing, Kristine AU - Ewing K AD - Department of Family Medicine, Naval Hospital Bremerton, 1 Boone Road, Bremerton, WA 98312, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Prim Care JT - Primary care JID - 0430463 SB - IM MH - Heart Diseases/*prevention & control MH - Humans MH - Metabolic Syndrome/*diagnosis/therapy MH - Risk Reduction Behavior MH - Systems Analysis OTO - NOTNLM OT - Diabetes prevention OT - Ectopic obesity OT - Insulin resistance OT - Metabolic syndrome EDAT- 2018/02/07 06:00 MHDA- 2018/08/31 06:00 CRDT- 2018/02/07 06:00 PHST- 2018/02/07 06:00 [entrez] PHST- 2018/02/07 06:00 [pubmed] PHST- 2018/08/31 06:00 [medline] AID - S0095-4543(17)30130-6 [pii] AID - 10.1016/j.pop.2017.10.003 [doi] PST - ppublish SO - Prim Care. 2018 Mar;45(1):109-129. doi: 10.1016/j.pop.2017.10.003.