PMID- 29407178
OWN - NLM
STAT- MEDLINE
DCOM- 20181224
LR  - 20181224
IS  - 1096-0309 (Electronic)
IS  - 0003-2697 (Linking)
VI  - 545
DP  - 2018 Mar 15
TI  - Voltammetric monitoring of linezolid, meropenem and theophylline in plasma.
PG  - 54-64
LID - S0003-2697(18)30010-1 [pii]
LID - 10.1016/j.ab.2018.01.009 [doi]
AB  - Treatment of healthcare associated Pneumonia (HCAP) caused by 
      Methicillin-resistant Staphylococcus aureus (MRSA) requires therapeutic protocols 
      formed of linezolid (LIN) either alone or in combination with meropenem (MERO) 
      and theophylline (THEO). The inter-individual pharmacokinetic variations require 
      the development of reliable therapeutic drug monitoring (TDM) tools especially in 
      immunocompromised patients. A sensitive square wave voltammetric sensor using 
      multiwalled carbon nanotubes (MWCNTs) modified carbon paste electrode in 
      Britton-Robinson buffer was developed and validated. Experimental parameters such 
      as pH, percentage of MWCNTs, and pre-concentration time were optimized. The 
      sensor was employed at pH 11.0 for the determination of LIN in plasma within a 
      concentration range of 2.5 x 10(-8) - 8.0 x 10(-6) mol L(-1)without interference 
      from co-administered medications. On the other hand, simultaneous monitoring of 
      LIN, MERO and THEO in plasma was feasible at pH 3.0 over concentration ranges of 
      4.0 x 10(-7)- 9.0 x 10(-5), 8.0 x 10(-7)- 9.0 x 10(-5) and 8.0 x 10(-7) - 
      9.0 x 10(-5) mol L(-1), respectively. The performance of the proposed sensor was 
      validated and the applicability for TDM has been demonstrated in plasma of 
      healthy volunteers.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Attia, Ali K
AU  - Attia AK
AD  - National Organization for Drug Control and Research, Cairo, Egypt. Electronic 
      address: alikamal1978@hotmail.com.
FAU - Al-Ghobashy, Medhat A
AU  - Al-Ghobashy MA
AD  - Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 
      Egypt; Bioanalysis Research Group, School of Pharmacy, New Giza University, 
      Egypt.
FAU - El-Sayed, Ghada M
AU  - El-Sayed GM
AD  - Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 
      Egypt.
FAU - Kamal, Samah M
AU  - Kamal SM
AD  - National Organization for Drug Control and Research, Cairo, Egypt.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anal Biochem
JT  - Analytical biochemistry
JID - 0370535
RN  - 0 (Nanotubes, Carbon)
RN  - C137DTR5RG (Theophylline)
RN  - FV9J3JU8B1 (Meropenem)
RN  - ISQ9I6J12J (Linezolid)
SB  - IM
MH  - *Electrochemical Techniques
MH  - Electrodes
MH  - Healthy Volunteers
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Linezolid/*blood
MH  - Meropenem/*blood
MH  - Nanotubes, Carbon/chemistry
MH  - Theophylline/*blood
OTO - NOTNLM
OT  - Carbon nanotubes
OT  - Linezolid
OT  - Meropenem
OT  - Plasma
OT  - Theophylline
OT  - Voltammetry
EDAT- 2018/02/07 06:00
MHDA- 2018/12/26 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/11/11 00:00 [received]
PHST- 2018/01/01 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/12/26 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S0003-2697(18)30010-1 [pii]
AID - 10.1016/j.ab.2018.01.009 [doi]
PST - ppublish
SO  - Anal Biochem. 2018 Mar 15;545:54-64. doi: 10.1016/j.ab.2018.01.009.