PMID- 29407302
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20211204
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 50
IP  - 1
DP  - 2018 Jan-Feb
TI  - Encapsulating Peritoneal Sclerosis in Peritoneal Dialysis Patients After Kidney 
      Transplantation.
PG  - 160-164
LID - S0041-1345(17)30978-8 [pii]
LID - 10.1016/j.transproceed.2017.12.054 [doi]
AB  - OBJECTIVE: Encapsulating peritoneal sclerosis (EPS) is a serious complication for 
      patients with chronic kidney disease (CKD) who were treated with long-term 
      peritoneal dialysis (PD). The risk of EPS was increased after kidney 
      transplantation. In our study we evaluated risk factors for EPS patients after 
      kidney transplantation who were treated before with PD. MATERIALS AND METHODS: In 
      our study, between January 2008 and August 2015, 47 PD patients (12 had EPS) who 
      underwent kidney transplantation were analyzed. Age, gender, time of PD 
      treatment, human leukocyte antigen (HLA) matching, cold ischemia time, kidney 
      function (serum urea, creatinine, etc), comorbidities, immunosuppressive therapy, 
      clinical features, and outcomes of PD patients were retrospectively evaluated in 
      both groups. RESULTS: Mean age was 42 (range, 25-60) years in EPS patients, 
      versus 43 (range, 22-77) years without EPS (P = .798). Distribution of gender was 
      similar in both groups (P = .154). The C-reactive protein levels (P < .001), 
      number of patients with peritonitis (P = .001), length of time on PD (P < .001), 
      and serum ferritin levels (P = .020) were higher in EPS patients. The 
      immunosuppressive therapy was changed; tamoxifen and steroids were used after 
      diagnosis in EPS patients. HLA matching was higher in the non-EPS group 
      (P = .006). EPS was more often seen in patients who were treated with continuous 
      ambulatory peritoneal dialysis (CAPD; 75%; P = .036). EPS was more often detected 
      in cadaveric transplant recipients (83.3%; P = .024). High peritoneal 
      transmittance rate was more identified in EPS (+) patients (P = .001). EPS was 
      more often seen in patients who were treated with icodextrin-based regimens in PD 
      before transplantation (91.7%; P = .037). The length of time on PD and high 
      ferritin levels increased EPS 1.08 and 1.01, respectively (P = .036 and .049, 
      respectively), in multivariate analysis. CONCLUSION: The length of time on PD, 
      type of PD, PD regimens with icodextrin, episodes of peritonitis, and peritoneal 
      transmittance in patients with CKD affect the development of EPS after 
      transplantation.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ayar, Y
AU  - Ayar Y
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey. Electronic address: yavuzayar@hotmail.com.
FAU - Ersoy, A
AU  - Ersoy A
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
FAU - Ocakoglu, G
AU  - Ocakoglu G
AD  - Uludag University Faculty of Medicine, Department of Bioistatistics, Bursa, 
      Turkey.
FAU - Gullulu, E
AU  - Gullulu E
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Bursa, 
      Turkey.
FAU - Kagizmanli, H
AU  - Kagizmanli H
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Bursa, 
      Turkey.
FAU - Yildiz, A
AU  - Yildiz A
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
FAU - Oruc, A
AU  - Oruc A
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
FAU - Yavuz, M
AU  - Yavuz M
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
FAU - Gullulu, M
AU  - Gullulu M
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
FAU - Dilek, K
AU  - Dilek K
AD  - Uludag University Faculty of Medicine, Department of Internal Medicine, Division 
      of Nephrology, Bursa, Turkey.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Dialysis Solutions)
RN  - 0 (Glucans)
RN  - 2NX48Z0A9G (Icodextrin)
RN  - AYI8EX34EU (Creatinine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Cold Ischemia/adverse effects
MH  - Creatinine/blood
MH  - Dialysis Solutions/adverse effects
MH  - Female
MH  - Glucans/adverse effects
MH  - Glucose/adverse effects
MH  - Humans
MH  - Icodextrin
MH  - Immunosuppression Therapy/adverse effects
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peritoneal Dialysis/*adverse effects
MH  - Peritoneal Fibrosis/*etiology
MH  - Peritoneum/physiopathology
MH  - Peritonitis/complications
MH  - Postoperative Complications/*etiology
MH  - Preoperative Period
MH  - Renal Insufficiency, Chronic/complications
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2018/02/07 06:00
MHDA- 2018/06/30 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/08/15 00:00 [received]
PHST- 2017/11/17 00:00 [revised]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
AID - S0041-1345(17)30978-8 [pii]
AID - 10.1016/j.transproceed.2017.12.054 [doi]
PST - ppublish
SO  - Transplant Proc. 2018 Jan-Feb;50(1):160-164. doi: 
      10.1016/j.transproceed.2017.12.054.