PMID- 29407528
OWN - NLM
STAT- MEDLINE
DCOM- 20190117
LR  - 20190117
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 97
DP  - 2018 Apr
TI  - The interplay between HIF-1 and calcium signalling in cancer.
PG  - 73-77
LID - S1357-2725(18)30029-3 [pii]
LID - 10.1016/j.biocel.2018.02.001 [doi]
AB  - The interplay between hypoxia-inducible factor-1 (HIF-1) and calcium in cancer 
      has begun to be unravelled with recent findings demonstrating the relationships 
      between the two in different cancer types. This is an area of significance 
      considering the crucial roles of both HIF-1 and calcium signalling in cancer 
      progression and metastasis. This review summarises the experimental evidence of 
      the crosstalk between HIF-1 and specific calcium channels, pumps and regulators 
      in the context of cancer. HIF-1 as a master regulator of hypoxic transcriptional 
      responses, mediates transcription of several calcium modulators. On the other 
      hand, specific calcium channels and pumps regulate HIF-1 activity through 
      controlling its transcription, translation, stabilisation, or nuclear 
      translocation. Identifying the interplay between HIF-1 and components of the 
      calcium signal will give new insights into mechanisms underlying cellular 
      responses to physiological and pathophysiological cues, and may provide novel and 
      more efficient therapeutic strategies for the control of cancer progression.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Azimi, Iman
AU  - Azimi I
AD  - Division of Pharmacy, College of Health and Medicine, University of Tasmania, 
      Hobart, TAS, Australia. Electronic address: iman.azimi@utas.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180203
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Calcium Channels)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Animals
MH  - Calcium Channels/genetics/*metabolism
MH  - *Calcium Signaling
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Neoplasms/genetics/*metabolism/pathology
OTO - NOTNLM
OT  - Calcium signalling
OT  - Cancer
OT  - HIF-1
EDAT- 2018/02/07 06:00
MHDA- 2019/01/18 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/01/18 00:00 [revised]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/01/18 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S1357-2725(18)30029-3 [pii]
AID - 10.1016/j.biocel.2018.02.001 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2018 Apr;97:73-77. doi: 10.1016/j.biocel.2018.02.001. 
      Epub 2018 Feb 3.