PMID- 29408022
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20220330
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 214
DP  - 2018 Feb
TI  - Vaccination with a porcine reproductive and respiratory syndrome virus vaccine at 
      1-day-old improved growth performance of piglets under field conditions.
PG  - 113-124
LID - S0378-1135(17)31020-9 [pii]
LID - 10.1016/j.vetmic.2017.12.023 [doi]
AB  - A porcine reproductive and respiratory syndrome virus (PRRSV) modified live-virus 
      (MLV) vaccine was evaluated under field conditions for registration as 
      recommended by the Republic of Korea's Animal, Plant & Fisheries Quarantine & 
      Inspection Agency. A single dose of the vaccine was administered to 1-day-old 
      piglets and their growth performance was monitored under field conditions. Three 
      separate farms were selected based on their history of PRRSV-associated 
      respiratory diseases. On each farm, 40 pigs were randomly allocated to one of two 
      treatment groups: (i) vaccinated (n = 20) and (ii) unvaccinated (n = 20) pigs at 
      1 day of age. Vaccinated pigs showed an increase of their market weight of 
      6.23 kg/pig compared to the unvaccinated pigs (98.01 kg in vaccinated group vs. 
      91.78 kg in unvaccinated group; P < 0.05) and exhibited a decrease in mortality 
      rate by 6.7% (3.3% in vaccinated group vs. 10% in unvaccinated group; P < 0.05). 
      The pigs had a sufficiently mature immune system for the vaccine to elicit 
      humoral and cell-mediated immunity (as measured by anti-PRRSV antibodies and 
      PRRSV-specific interferon-gamma secreting cells, respectively) at 1 day of age even 
      in the presence of maternally derived antibodies. The results presented in this 
      study demonstrate that the PRRSV MLV vaccine is effective in improving growth 
      performance from day 1 all the way to day 182 in endemic farms suffering with 
      PRRSV-2 infection or both PRRSV-1 and PRRSV-2 infection.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Kim, Seeun
AU  - Kim S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20171229
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Viral
MH  - Farms
MH  - Immunity, Cellular
MH  - Immunity, Humoral
MH  - Immunity, Maternally-Acquired
MH  - Interferon-gamma/immunology
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/immunology/*prevention 
      & control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Republic of Korea/epidemiology
MH  - Swine
MH  - Vaccination/*veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/administration & dosage/*immunology
OTO - NOTNLM
OT  - 1-day-old pig
OT  - Maternally derived antibodies
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Vaccination
EDAT- 2018/02/07 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2017/12/27 00:00 [revised]
PHST- 2017/12/28 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
AID - S0378-1135(17)31020-9 [pii]
AID - 10.1016/j.vetmic.2017.12.023 [doi]
PST - ppublish
SO  - Vet Microbiol. 2018 Feb;214:113-124. doi: 10.1016/j.vetmic.2017.12.023. Epub 2017 
      Dec 29.