PMID- 29408183
OWN - NLM
STAT- MEDLINE
DCOM- 20180719
LR  - 20211204
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 69
DP  - 2018 Apr
TI  - Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR 
      inhibitor therapy: A case report.
PG  - 75-77
LID - S1201-9712(18)30034-1 [pii]
LID - 10.1016/j.ijid.2018.01.033 [doi]
AB  - A 67-year-old man presented to the hospital with complaints of fever and cough. 
      He had a past medical history of renal cell carcinoma and had just started 
      treatment with temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor. A 
      1-week course of antibiotics did not have any effect on his symptoms. A chest 
      computed tomography (CT) scan showed the reversed halo sign (RHS). Organizing 
      pneumonia induced by mTOR inhibitor treatment was initially considered. However, 
      transbronchial biopsy revealed clusters of fungal organisms, suggesting infection 
      with Aspergillus spp. Within just 2 weeks, a CT scan showed drastic enlargement 
      of the cavitary lesion, with multiple newly formed consolidations. The patient 
      was diagnosed with invasive pulmonary aspergillosis. Concomitant treatment with 
      voriconazole and micafungin was started. Two weeks after the initiation of 
      treatment, he became afebrile with gradual regression of the cavitary lesion and 
      consolidations.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Iijima, Yuki
AU  - Iijima Y
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Fujioka, Namiko
AU  - Fujioka N
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Uchida, Yoshinori
AU  - Uchida Y
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Kobayashi, Yoichi
AU  - Kobayashi Y
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Tsutsui, Toshiharu
AU  - Tsutsui T
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Kakizaki, Yumiko
AU  - Kakizaki Y
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
FAU - Miyashita, Yoshihiro
AU  - Miyashita Y
AD  - Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital, 1-1-1 
      Fujimi, Kofu City, Yamanashi 400-8506, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180203
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Echinocandins)
RN  - 0 (Lipopeptides)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - JFU09I87TR (Voriconazole)
RN  - R10H71BSWG (Micafungin)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aged
MH  - Aspergillus/isolation & purification
MH  - Carcinoma, Renal Cell/drug therapy
MH  - Echinocandins/therapeutic use
MH  - Humans
MH  - Invasive Pulmonary Aspergillosis/*diagnosis/*drug therapy
MH  - Lipopeptides/therapeutic use
MH  - Male
MH  - Micafungin
MH  - Pneumonia
MH  - Sirolimus/administration & dosage/*adverse effects
MH  - TOR Serine-Threonine Kinases/*antagonists & inhibitors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Voriconazole/therapeutic use
OTO - NOTNLM
OT  - Immunocompromise
OT  - Invasive pulmonary aspergillosis
OT  - Organizing pneumonia
OT  - Reversed halo sign
OT  - mTOR inhibitor
EDAT- 2018/02/07 06:00
MHDA- 2018/07/20 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/12/28 00:00 [received]
PHST- 2018/01/28 00:00 [revised]
PHST- 2018/01/29 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/07/20 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S1201-9712(18)30034-1 [pii]
AID - 10.1016/j.ijid.2018.01.033 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2018 Apr;69:75-77. doi: 10.1016/j.ijid.2018.01.033. Epub 2018 
      Feb 3.