PMID- 29408239
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20190914
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 88
DP  - 2018 Apr
TI  - Prefrontal cortical parvalbumin and somatostatin expression and cell density 
      increase during adolescence and are modified by BDNF and sex.
PG  - 177-188
LID - S1044-7431(17)30310-X [pii]
LID - 10.1016/j.mcn.2018.02.001 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is known to play a critical role early 
      in the development of cortical GABAergic interneurons. Recently our laboratory 
      and others have shown protracted development of specific subpopulations of 
      GABAergic interneurons extending into adolescence. BDNF expression also changes 
      significantly across adolescent development. However the role of BDNF in 
      regulating GABAergic changes across adolescence remains unclear. Here, we 
      performed a week-by-week analysis of the protein expression and cell density of 
      three major GABAergic interneurons, parvalbumin (PV), somatostatin (SST) and 
      calretinin (Cal) in the medial prefrontal cortex from prepubescence (week 3) to 
      adulthood (week 12). In order to assess how BDNF and sex might influence the 
      adolescent trajectory of GABAergic interneurons we compared WT as well as BDNF 
      heterozygous (+/-) male and female mice. In both males and females PV expression 
      increases during adolescent development in the mPFC. Compared to wild-types, PV 
      expression was reduced in male but not female BDNF+/- mice throughout adolescent 
      development. This reduction in protein expression corresponded with reduced cell 
      density, specifically within the infralimbic prefrontal cortex. SST expression 
      increased in early adolescent WT females and this upregulation was delayed in 
      BDNF+/-. SST cell density also increased in early adolescent mPFC of WT female 
      mice, with BDNF+/- again showing a reduced pattern of expression. Cal protein 
      expression was also sex-dependently altered across adolescence with WT males 
      showing a steady decline but that of BDNF+/- remaining unaltered. Reduced cell 
      density in on the other hand was observed particularly in male BDNF+/- mice. In 
      females, Cal protein expression and cell density remained largely stable. Our 
      results show that PV, SST and calretinin interneurons are indeed still developing 
      into early adolescence in the mPFC and that BDNF plays a critical, sex-specific 
      role in mediating expression and cell density.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Du, X
AU  - Du X
AD  - Behavioural Neuroscience Laboratory, Department of Psychiatry, Monash University, 
      Clayton, Victoria 3168, Australia. Electronic address: xin.du@monash.edu.
FAU - Serena, K
AU  - Serena K
AD  - Psychoneuroendocrinology Laboratory, Florey Institute for Neuroscience and Mental 
      Health, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Hwang, Wu Jeong
AU  - Hwang WJ
AD  - Psychoneuroendocrinology Laboratory, Florey Institute for Neuroscience and Mental 
      Health, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Grech, A M
AU  - Grech AM
AD  - Behavioural Neuroscience Laboratory, Department of Psychiatry, Monash University, 
      Clayton, Victoria 3168, Australia.
FAU - Wu, Y W C
AU  - Wu YWC
AD  - Psychoneuroendocrinology Laboratory, Florey Institute for Neuroscience and Mental 
      Health, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Schroeder, A
AU  - Schroeder A
AD  - Psychoneuroendocrinology Laboratory, Florey Institute for Neuroscience and Mental 
      Health, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Hill, R A
AU  - Hill RA
AD  - Behavioural Neuroscience Laboratory, Department of Psychiatry, Monash University, 
      Clayton, Victoria 3168, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180203
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calbindin 2)
RN  - 0 (Parvalbumins)
RN  - 51110-01-1 (Somatostatin)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Calbindin 2/metabolism
MH  - Cell Count
MH  - Female
MH  - Glutamate Decarboxylase/metabolism
MH  - Interneurons/metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Parvalbumins/*metabolism
MH  - Prefrontal Cortex/*metabolism
MH  - Sex Factors
MH  - Somatostatin/*metabolism
OTO - NOTNLM
OT  - Adolescence
OT  - BDNF
OT  - GABAergic interneurons
OT  - Gender-difference
OT  - Schizophrenia
EDAT- 2018/02/07 06:00
MHDA- 2019/02/01 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2018/01/25 00:00 [revised]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S1044-7431(17)30310-X [pii]
AID - 10.1016/j.mcn.2018.02.001 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2018 Apr;88:177-188. doi: 10.1016/j.mcn.2018.02.001. Epub 2018 
      Feb 3.