PMID- 29408452
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 104
DP  - 2018 Apr
TI  - Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic 
      factor levels in elderly women.
PG  - 60-65
LID - S0531-5565(17)30886-0 [pii]
LID - 10.1016/j.exger.2018.01.024 [doi]
AB  - BACKGROUND: The increase in the prevalence of degenerative brain diseases owing 
      to the growing elderly population is becoming a serious social issue, and regular 
      exercises can be effective in preventing and treating such diseases. Irisin, one 
      of the myokines expressed in the muscles during exercise, is highly associated 
      with the expression of brain-derived neurotrophic factor (BDNF). Therefore, the 
      purpose of this study was to analyze the effect of aquarobic exercises on serum 
      irisin and BDNF levels to help prevent and delay degenerative brain diseases in 
      elderly women. MATERIALS AND METHODS: Twenty-six elderly women voluntarily 
      participated in the study (12 in the control group and 14 in the exercise group). 
      The exercise group underwent a 16-week aquarobic exercise program. The irisin and 
      BDNF levels and liver function were measured in both groups: three times in the 
      exercise group and two times in the control group. RESULTS: Significantly higher 
      serum irisin (p < 0.001) and BDNF (p < 0.05) levels in the aquarobic exercise 
      group than in the control group were found after 16 weeks of exercise, and 
      significant interaction effects of irisin (p < 0.001) and BDNF (p < 0.01) were 
      found in both the control and exercise groups. The serum irisin (p < 0.01 and 
      p < 0.001, respectively) and BDNF (p < 0.05, p < 0.001, respectively) levels were 
      significantly higher 30 min after the first exercise session and 30 min after the 
      last exercise session in the 16th week than during the rest period before the 
      16 weeks of exercise. CONCLUSIONS: Aquarobic exercises were found to improve the 
      serum irisin and BDNF levels; thus, it could be effective in preventing 
      degenerative brain diseases and enhancing brain function of elderly women.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Kim, Ji-Hyeon
AU  - Kim JH
AD  - Department of Physical Education, Pusan National University, Busan, South Korea.
FAU - Kim, Do-Yeon
AU  - Kim DY
AD  - Department of Physical Education, Pusan National University, Busan, South Korea. 
      Electronic address: kdy4955@pusan.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180206
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Brain Diseases/blood/prevention & control
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exercise/physiology
MH  - *Exercise Therapy
MH  - Female
MH  - Fibronectins/*metabolism
MH  - Humans
MH  - Neurodegenerative Diseases/blood/prevention & control
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aquarobic exercise
OT  - BDNF
OT  - Elderly women
OT  - Irisin
EDAT- 2018/02/07 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/01/23 00:00 [revised]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S0531-5565(17)30886-0 [pii]
AID - 10.1016/j.exger.2018.01.024 [doi]
PST - ppublish
SO  - Exp Gerontol. 2018 Apr;104:60-65. doi: 10.1016/j.exger.2018.01.024. Epub 2018 Feb 
      6.