PMID- 29408706
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 138
DP  - 2018 Apr
TI  - Population-based cohort study suggesting a significantly increased risk of 
      developing chronic obstructive pulmonary disease in people with type 2 diabetes 
      mellitus.
PG  - 66-74
LID - S0168-8227(17)31651-0 [pii]
LID - 10.1016/j.diabres.2018.01.037 [doi]
AB  - AIMS: To investigate whether type 2 diabetes mellitus (T2DM) increases the risk 
      of developing chronic obstructive pulmonary disease (COPD). METHODS: This 
      population-based cohort study used Taiwan's National Health insurance claim data 
      to investigate the association of T2DM with the risk of COPD. A total of 716,623 
      pairs of people (patients with T2DM and their age-, sex-, and calendar 
      year-matched controls) were identified in 2002-2003 and were followed until the 
      occurrence of newly-diagnosed COPD or the end of 2011. Cox proportional hazard 
      models were used to relate COPD incidence to T2DM. RESULTS: People with T2DM 
      experienced a higher incidence rate of COPD than controls (159.6 vs 122.7 per 
      10(4) person-years). After controlling for confounders, T2DM significantly 
      increased the hazard of COPD (hazard ratio [HR] = 1.15, 95% confidence 
      interval = 1.14-1.16). Stratified analysis indicated that the association between 
      T2DM and COPD was slightly greater in women than in men (HR, 1.15 vs. 1.11) and 
      in people aged <65 years than in people aged >/=65 years (HR, 1.17 vs. 1.05 in men; 
      1.16 vs. 1.13 in women). CONCLUSIONS: Our findings demonstrated a modest 
      association of T2DM with the risk of developing COPD, possibly shedding light 
      into the adverse effects of hyperglycemia on pulmonary function.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hsu, I-Lin
AU  - Hsu IL
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan; Department of Emergency Medicine, National Cheng Kung University 
      Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Lu, Chin-Li
AU  - Lu CL
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Li, Chia-Chun
AU  - Li CC
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Tsai, Sheng-Han
AU  - Tsai SH
AD  - Division of Chest Medicine, Department of Internal Medicine, College of Medicine 
      and Hospital, National Cheng Kung University, Tainan, Taiwan.
FAU - Chen, Chiung-Zuei
AU  - Chen CZ
AD  - Division of Chest Medicine, Department of Internal Medicine, College of Medicine 
      and Hospital, National Cheng Kung University, Tainan, Taiwan.
FAU - Hu, Susan C
AU  - Hu SC
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Li, Chung-Yi
AU  - Li CY
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan; Department of Public Health, College of Public Health, China 
      Medical University, Taichung, Taiwan. Electronic address: 
      cyli99@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20180203
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*etiology/pathology
MH  - Risk
OTO - NOTNLM
OT  - COPD
OT  - Cohort study
OT  - Population-based study
OT  - Type 2 diabetes mellitus
EDAT- 2018/02/07 06:00
MHDA- 2018/06/02 06:00
CRDT- 2018/02/07 06:00
PHST- 2017/10/18 00:00 [received]
PHST- 2018/01/05 00:00 [revised]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - S0168-8227(17)31651-0 [pii]
AID - 10.1016/j.diabres.2018.01.037 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Apr;138:66-74. doi: 10.1016/j.diabres.2018.01.037. 
      Epub 2018 Feb 3.