PMID- 29409879
OWN - NLM
STAT- MEDLINE
DCOM- 20180314
LR  - 20180513
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 496
IP  - 4
DP  - 2018 Feb 19
TI  - Soluble FLT-1 rules placental destiny.
PG  - 1243-1249
LID - S0006-291X(18)30209-2 [pii]
LID - 10.1016/j.bbrc.2018.01.180 [doi]
AB  - INTRODUCTION: Placenta previa is an abnormality in which the placenta covers the 
      internal uterine os, and it can cause serious morbidity and mortality in both 
      mother and fetus due to catastrophic hemorrhage. Some pregnant women recover from 
      placenta previa due to a phenomenon called "migration." However, the mechanism of 
      "migration" of the placenta has not been elucidated. METHODS: Human placentas 
      were collected from patients with placenta previa and those with no abnormal 
      placentation (control). A microarray analysis was performed to detect the genes 
      up- or down-regulated only in the caudal part in the previa group. Specific mRNA 
      expression was evaluated using real-time quantitative reverse transcription PCR 
      (qRT-PCR). Unilateral uterine artery ablation of 8.5 dpc mice was performed to 
      reproduce the reduction of placental blood supply, and weights of the placentas 
      and fetuses were evaluated in 18.5 dpc. Specific mRNA expression was also 
      evaluated in mice placentas. RESULTS: According to the result of the microarray 
      analysis, we focused on soluble fms-like tyrosine kinase-1 (sFLT-1) and 
      hypoxia-inducible factor-1 (HIF-1) alpha. The sFLT-1 expression level is locally 
      high in the caudal part of the human placenta in patients with placenta previa. 
      In mice experiments, the weights of the placentas and fetuses were significantly 
      smaller in the ablation side than those in the control side, and the sFlt-1 
      expression level was significantly higher in the ablation side than in the 
      control side. DISCUSSION: Our study suggests that "migration" of the placenta is 
      derived from placental degeneration at the caudal part of the placenta, and 
      sFlt-1 plays a role in this placental degeneration.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Yamashita, Michiko
AU  - Yamashita M
AD  - Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka 
      University, Osaka, Japan. Electronic address: uri_ton@hotmail.com.
FAU - Kumasawa, Keiichi
AU  - Kumasawa K
AD  - Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka 
      University, Osaka, Japan. Electronic address: kumasawa@gyne.med.osaka-u.ac.jp.
FAU - Nakamura, Hitomi
AU  - Nakamura H
AD  - Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka 
      University, Osaka, Japan. Electronic address: hitomi@gyne.med.osaka-u.ac.jp.
FAU - Kimura, Tadashi
AU  - Kimura T
AD  - Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka 
      University, Osaka, Japan. Electronic address: tadashi@gyne.med.osaka-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20180131
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - EC 2.7.10.1 (FLT1 protein, human)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
EIN - Biochem Biophys Res Commun. 2018 May 9;:. PMID: 29753561
MH  - Adult
MH  - Animals
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - In Vitro Techniques
MH  - Mice, Inbred ICR
MH  - Middle Aged
MH  - Organ Specificity
MH  - Placenta/*metabolism
MH  - Placenta Previa/*mortality
MH  - *Placentation
MH  - Pregnancy
MH  - Species Specificity
MH  - Tissue Distribution
MH  - Vascular Endothelial Growth Factor Receptor-1/*metabolism
OTO - NOTNLM
OT  - Placenta previa
OT  - Placental migration
OT  - Soluble fms-like tyrosine kinase-1 (sFLT-1)
EDAT- 2018/02/08 06:00
MHDA- 2018/03/15 06:00
CRDT- 2018/02/08 06:00
PHST- 2018/01/20 00:00 [received]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2018/03/15 06:00 [medline]
PHST- 2018/02/08 06:00 [entrez]
AID - S0006-291X(18)30209-2 [pii]
AID - 10.1016/j.bbrc.2018.01.180 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Feb 19;496(4):1243-1249. doi: 
      10.1016/j.bbrc.2018.01.180. Epub 2018 Jan 31.