PMID- 29411984
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20180917
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 17
IP  - 3
DP  - 2018 Mar 2
TI  - Two Fungicides Alter Reproduction of the Small Brown Planthopper Laodelphax 
      striatellus by Influencing Gene and Protein Expression.
PG  - 978-986
LID - 10.1021/acs.jproteome.7b00612 [doi]
AB  - Aside from their intended actions, fungicides can drive pest insect outbreaks due 
      to virtually continuous use and pest evolution. Small brown planthopper (SBPH), 
      Laodelphax striatellus, outbreaks occurred recently in many provinces in China, 
      with devastating rice losses. Because exposure to the fungicide jinggangmycin 
      (JGM) increased reproduction of the brown plant hopper, Nilaparvata lugens, via 
      its influence on fatty acid synthase, we posed the hypothesis that JGM and 
      carbendazim (CBM) influence SBPH reproduction via their influence on enzymes 
      involved in other aspects of lipid metabolism. Exposure to the fungicide CBM 
      stimulated SBPH reproduction (egg-laying up by 78%) and to another fungicide, 
      JGM, led to decreased egg-laying (down by 47.3%). These inverse effects are 
      mediated by down-regulated expression of l-3-hydroxyacyl-coenzyme A dehydrogenase 
      (LCHAD) in JGM-treated females and up-regulated expression of hydroxysteroid 
      dehydrogenase-like protein 2-like (HSD) in CBM-treated females. RNAi knockdown 
      of, separately, LCHAD and HSD led to reduced egg-laying (down by 52% for dsLCHAD 
      and by 73% for dsHSD). dsLCHAD, dsHSD, and JGM treatments also led to severely 
      reduced ovarian development in experimental SBPH, with shorted and thinned 
      valvula and lack of egg cells in ovaries. Valvula of CBM-treated females 
      enlarged, with banana-shaped eggs in ovaries. These data strongly support our 
      hypothesis.
FAU - Wu, You
AU  - Wu Y
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Ding, Jun
AU  - Ding J
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Xu, Bing
AU  - Xu B
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - You, Linlin
AU  - You L
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Ge, Linquan
AU  - Ge L
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Yang, Guoqing
AU  - Yang G
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Liu, Fang
AU  - Liu F
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
FAU - Stanley, David
AU  - Stanley D
AD  - Biological Control of Insects Research Laboratory, USDA/Agricultural Research 
      Service , 1503 South Providence Road, Columbia, Missouri 65203, United States.
FAU - Song, Qisheng
AU  - Song Q
AD  - Division of Plant Sciences, University of Missouri , 1-31 Agriculture Building, 
      Columbia, Missouri 65211, United States.
FAU - Wu, Jincai
AU  - Wu J
AD  - School of Plant Protection, Yangzhou University , Yangzhou 225009, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180220
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (Benzimidazoles)
RN  - 0 (Carbamates)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Insect Proteins)
RN  - 0 (Proteome)
RN  - 0 (RNA, Small Interfering)
RN  - 313E9620QS (validamycin A)
RN  - 4L6452S749 (Inositol)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.211 (Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase)
RN  - H75J14AA89 (carbendazim)
SB  - IM
MH  - Animals
MH  - Benzimidazoles/*pharmacology
MH  - Carbamates/*pharmacology
MH  - Female
MH  - Fertility/drug effects/genetics
MH  - Fungicides, Industrial/*pharmacology
MH  - Gene Expression Regulation
MH  - Gene Ontology
MH  - Hemiptera/*drug effects/enzymology/genetics/growth & development
MH  - Hydroxysteroid Dehydrogenases/antagonists & inhibitors/*genetics/metabolism
MH  - Inositol/*analogs & derivatives/pharmacology
MH  - Insect Proteins/classification/genetics/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase/antagonists & 
      inhibitors/*genetics/metabolism
MH  - Molecular Sequence Annotation
MH  - Oryza/parasitology
MH  - Ovary/drug effects/enzymology/growth & development
MH  - Oviposition/drug effects
MH  - Proteome/genetics/metabolism
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Reproduction/*drug effects/genetics
MH  - Zygote/drug effects/enzymology/growth & development
OTO - NOTNLM
OT  - HSD
OT  - LCHAD
OT  - Laodelphax striatellus
OT  - carbendazim
OT  - jinggangmycin
OT  - reproduction
OT  - vector insect
EDAT- 2018/02/08 06:00
MHDA- 2018/09/18 06:00
CRDT- 2018/02/08 06:00
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/02/08 06:00 [entrez]
AID - 10.1021/acs.jproteome.7b00612 [doi]
PST - ppublish
SO  - J Proteome Res. 2018 Mar 2;17(3):978-986. doi: 10.1021/acs.jproteome.7b00612. 
      Epub 2018 Feb 20.