PMID- 29412381
OWN - NLM
STAT- MEDLINE
DCOM- 20180425
LR  - 20231003
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 61
IP  - 6
DP  - 2017 Dec
TI  - Obese with higher FNDC5/Irisin levels have a better metabolic profile, lower 
      lipopolysaccharide levels and type 2 diabetes risk.
PG  - 524-533
LID - S2359-39972017000600524 [pii]
LID - 10.1590/2359-3997000000305 [doi]
AB  - OBJECTIVE: Thus, the aim of this study was to compare if higher or smaller 
      fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin levels are 
      associated with inflammatory and metabolic markers, caloric/macronutrient intake, 
      physical fitness and type 2 diabetes mellitus (T2DM) risk in obese middle-aged 
      men, and also to correlate all variables analyzed with FNDC5/irisin. SUBJECTS AND 
      METHODS: On the basis of a cluster study, middle-aged obese men (IMC: 31.01 +/- 
      1.64 kg/m2) were divided into groups of higher and smaller levels of 
      FNDC5/irisin. The levels of leptin, resistin, adiponectin, tumor necrosis factor 
      alpha (TNFalpha), interleukin 6 and 10 (IL6, IL10), lipopolysaccharide (LPS), 
      glucose, insulin, glycated hemoglobin, insulin resistance and sensibility, lipid 
      profile, risk of T2DM development, body composition, rest energy expenditure, 
      caloric/macronutrient intake and physical fitness were measured. RESULTS: The 
      higher FNDC5/ irisin group presented improved insulin sensibility (homeostasis 
      model assessment - sensibility (HOMA-S) (p = 0.01) and QUICKI index (p < 0.01)), 
      insulin (p = 0.02) and triglyceride levels (p = 0.01), lower insulin resistance 
      (homeostasis model assessment - insulin resistance (HOMA-IR) (p = 0.01), 
      triglycerides/glucose (TYG index) (p = 0.02), neck circumference (p = 0.02), risk 
      of T2DM development (p = 0.02), tendency to decrease serum resistin (p = 0.08) 
      and significant lower LPS levels (p = 0.02). Inverse correlations between 
      FNDC5/irisin and body weight (r -0.46, p = 0.04), neck circumference (r -0.51, p 
      = 0.02), free fat mass (r -0.49, p = 0.02), triglycerides (r -0.43, p = 0.05) and 
      risk of developing T2DM (r -0.61, p = 0.04) were observed. CONCLUSIONS: These 
      results suggest that higher FNDC5/irisin levels in obese middle-aged men are 
      related to a better metabolic profile and lower risk of T2DM development and 
      serum LPS, a potential inducer of insulin resistance.
FAU - Bonfante, Ivan Luiz Padilha
AU  - Bonfante ILP
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
FAU - Chacon-Mikahil, Mara Patricia Traina
AU  - Chacon-Mikahil MPT
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
FAU - Brunelli, Diego Trevisan
AU  - Brunelli DT
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
FAU - Gaspari, Arthur Fernandes
AU  - Gaspari AF
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
FAU - Duft, Renata Garbellini
AU  - Duft RG
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
FAU - Oliveira, Alexandre Gabarra
AU  - Oliveira AG
AD  - Instituto de Biociencias, Universidade Estadual Paulista "Julio de Mesquita 
      Filho" (Unesp), Rio Claro, SP, Brasil.
FAU - Araujo, Tiago Gomes
AU  - Araujo TG
AD  - Departamento de Medicina Interna, Escola de Ciencias Medicas, Universidade 
      Estadual de Campinas (Unicamp), Campinas, SR Brasil.
FAU - Saad, Mario Jose Abdalla
AU  - Saad MJA
AD  - Departamento de Medicina Interna, Escola de Ciencias Medicas, Universidade 
      Estadual de Campinas (Unicamp), Campinas, SR Brasil.
FAU - Cavaglieri, Claudia Regina
AU  - Cavaglieri CR
AD  - Laboratorio de Fisiologia do Exercicio, Faculdade de Educacao Fisica, 
      Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
RN  - 0 (Biomarkers)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Pressure/physiology
MH  - Cardiorespiratory Fitness/physiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*etiology/physiopathology
MH  - Energy Intake/physiology
MH  - Exercise Test
MH  - Fibronectins/*blood
MH  - Humans
MH  - Lipopolysaccharides/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/*complications/physiopathology
MH  - Risk Factors
PMC - PMC10522056
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2018/02/08 06:00
MHDA- 2018/04/26 06:00
PMCR- 2017/12/01
CRDT- 2018/02/08 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2017/06/06 00:00 [accepted]
PHST- 2018/02/08 06:00 [entrez]
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2018/04/26 06:00 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - S2359-39972017000600524 [pii]
AID - 2359-3997000000305 [pii]
AID - 10.1590/2359-3997000000305 [doi]
PST - ppublish
SO  - Arch Endocrinol Metab. 2017 Dec;61(6):524-533. doi: 10.1590/2359-3997000000305.