PMID- 29413815
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20200718
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 50
DP  - 2018 Feb
TI  - Natural killer cell education in human health and disease.
PG  - 102-111
LID - S0952-7915(17)30169-3 [pii]
LID - 10.1016/j.coi.2017.11.003 [doi]
AB  - Natural killer (NK) cells maintain immune homeostasis by detecting and 
      eliminating damaged cells. Simultaneous activating and inhibitory input are 
      integrated by NK cells, with the net signal prompting cytotoxicity and cytokine 
      production, or inhibition. Chief among the inhibitory ligands for NK cells are 
      'self' human leukocyte antigen (HLA) molecules, which are sensed by killer 
      immunoglobulin-like receptors (KIR). Through a process called 'education', the 
      functional capabilities of each NK cell are counterbalanced by their sensitivity 
      for inhibition by co-inherited 'self' HLA. HLA and their ligands, the killer 
      immunoglobulin-like receptors (KIR), are encoded by polymorphic, polygenic gene 
      loci that segregate independently, therefore, NK education and function differ 
      even between related individuals. In this review, we describe how variation in NK 
      education, reactivity and sensitivity for inhibition impacts reproductive 
      success, infection, cancer, inflammatory and autoimmune diseases.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Boudreau, Jeanette E
AU  - Boudreau JE
AD  - Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; 
      Department of Pathology, Dalhousie University, Halifax, Canada.
FAU - Hsu, Katharine C
AU  - Hsu KC
AD  - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 
      USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. 
      Electronic address: hsuk@mskcc.org.
LA  - eng
GR  - R01 AI125651/AI/NIAID NIH HHS/United States
GR  - P01 CA023766/CA/NCI NIH HHS/United States
GR  - U01 AI069197/AI/NIAID NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - R56 AI123658/AI/NIAID NIH HHS/United States
GR  - R01 HL129472/HL/NHLBI NIH HHS/United States
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180203
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/etiology/metabolism
MH  - Autoimmunity
MH  - Communicable Diseases/etiology/metabolism
MH  - Disease Resistance/immunology
MH  - *Disease Susceptibility
MH  - Female
MH  - Humans
MH  - *Immunity
MH  - Inflammation/etiology/metabolism
MH  - Killer Cells, Natural/*immunology/*metabolism
MH  - Lymphocyte Activation/immunology
MH  - Neoplasms/etiology/metabolism
MH  - Pregnancy
PMC - PMC5958620
MID - NIHMS925921
EDAT- 2018/02/08 06:00
MHDA- 2019/04/02 06:00
PMCR- 2019/02/03
CRDT- 2018/02/08 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2017/11/18 00:00 [accepted]
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/02/08 06:00 [entrez]
PHST- 2019/02/03 00:00 [pmc-release]
AID - S0952-7915(17)30169-3 [pii]
AID - 10.1016/j.coi.2017.11.003 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2018 Feb;50:102-111. doi: 10.1016/j.coi.2017.11.003. Epub 2018 
      Feb 3.