PMID- 29414128 OWN - NLM STAT- MEDLINE DCOM- 20190305 LR - 20190305 IS - 1872-7506 (Electronic) IS - 0925-4927 (Linking) VI - 273 DP - 2018 Mar 30 TI - The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder. PG - 25-34 LID - S0925-4927(17)30269-X [pii] LID - 10.1016/j.pscychresns.2018.01.005 [doi] AB - The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD). We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients with MDD and 65 healthy participants aged 20-65 years were recruited. The subjects were genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms and scanned with T1-weighted and diffusion tensor imaging. The gray matter volumes of 24 gyri in the prefrontal and anterior cingulate cortices and the fractional anisotropy values of nine white matter tracts in both hemispheres were determined. In the pooled sample of subjects from both groups, 5-HTTLPR L-allele carriers had significantly decreased cortical volume in the right anterior midcingulate gyrus compared to S-allele homozygotes. A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed. Our results suggested that these genetic polymorphisms play important roles in the neurostructural changes of emotion-processing regions in subjects with MDD. CI - Copyright (c) 2018 Elsevier B.V. All rights reserved. FAU - Han, Kyu-Man AU - Han KM AD - Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. FAU - Choi, Sunyoung AU - Choi S AD - Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea. FAU - Kim, Aram AU - Kim A AD - Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea. FAU - Kang, June AU - Kang J AD - Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea. FAU - Won, Eunsoo AU - Won E AD - Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. FAU - Tae, Woo-Suk AU - Tae WS AD - Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea. FAU - Kim, Yong-Ku AU - Kim YK AD - Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea. FAU - Lee, Min-Soo AU - Lee MS AD - Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. FAU - Ham, Byung-Joo AU - Ham BJ AD - Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea; Brain Convergence Research Center, Korea University Anam Hospital, Seoul, Republic of Korea. Electronic address: hambj@korea.ac.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180202 PL - Netherlands TA - Psychiatry Res Neuroimaging JT - Psychiatry research. Neuroimaging JID - 101723001 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Alleles MH - Anisotropy MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Depressive Disorder, Major/*genetics/*pathology MH - Diffusion Tensor Imaging MH - Emotions MH - Female MH - Genotype MH - Gray Matter/pathology MH - Gyrus Cinguli/pathology MH - Humans MH - Male MH - Middle Aged MH - Organ Size MH - *Polymorphism, Genetic MH - Serotonin Plasma Membrane Transport Proteins/*genetics MH - White Matter/pathology OTO - NOTNLM OT - 5-HTTLPR OT - Anterior cingulate cortex OT - BDNF Val66met polymorphism OT - Depression OT - Uncinate fasciculus EDAT- 2018/02/08 06:00 MHDA- 2019/03/06 06:00 CRDT- 2018/02/08 06:00 PHST- 2017/09/26 00:00 [received] PHST- 2017/12/07 00:00 [revised] PHST- 2018/01/22 00:00 [accepted] PHST- 2018/02/08 06:00 [pubmed] PHST- 2019/03/06 06:00 [medline] PHST- 2018/02/08 06:00 [entrez] AID - S0925-4927(17)30269-X [pii] AID - 10.1016/j.pscychresns.2018.01.005 [doi] PST - ppublish SO - Psychiatry Res Neuroimaging. 2018 Mar 30;273:25-34. doi: 10.1016/j.pscychresns.2018.01.005. Epub 2018 Feb 2.