PMID- 29414320
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20190429
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 104
DP  - 2018 Apr
TI  - Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio 
      as predictors of complete remission in primary glomerulonephritis.
PG  - 1-7
LID - S1043-4666(18)30015-2 [pii]
LID - 10.1016/j.cyto.2018.01.015 [doi]
AB  - BACKGROUND: The balance of several cytokines likely influences the resolution of 
      glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that 
      promotes renal inflammation whereas epidermal growth factor (EGF) stimulates 
      protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF) 
      levels were found to be associated with tubulointerstitial fibrosis, but there is 
      limited information on the value of these mediators as predictors of therapeutic 
      responses or long term outcome in primary glomerulonephritis. OBJECTIVES: To 
      determine the performance of urine EGF, MCP-1 or their ratio at baseline as 
      biomarkers to predict complete remission, and the relationship of these mediators 
      with subsequent renal function 24 months later in primary glomerulonephritis. 
      METHODS: This is a prospective study of patients with biopsy-proven primary 
      glomerulonephritis. Baseline urine samples were collected at biopsy before 
      therapy. MCP-1 and EGF were analyzed by enzyme-linked immunosorbent assays and 
      expressed as a ratio to urine creatinine (ng/mgCr) or as EGF/MCP-1 ratio (ng/ng). 
      Proteinuria and estimated glomerular filtration rate (eGRF) were monitored after 
      therapy. Complete remission (CR) was defined as proteinuria </= 0.3 g/gCr. RESULTS: 
      Median follow-up was 20 months. Of all patients (n = 74), 38 patients (51.4%) 
      subsequently achieved CR. Baseline urine EGF and EGF/MCP-1 levels were 
      significantly higher in CR compared to Not CR. By contrast, MCP-1 was not 
      different. High EGF (EGF > 75 ng/mgCr) was a significant predictor (OR 2.28) for 
      CR by multivariate analysis after adjusting for proteinuria, blood pressure, 
      baseline eGFR. In patients who completed 24 months follow-up (n = 43), baseline 
      EGF correlated inversely with proteinuria and positively with eGFR at 24 months. 
      CONCLUSION: High urine EGF level is a promising biomarker of CR. Baseline EGF 
      levels correlated with kidney function at 2 years. EGF/MCP-1 was not superior to 
      EGF alone. Further studies are necessary to determine the role of urine EGF as a 
      guide to therapy in primary GN.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Chanrat, Eakkapat
AU  - Chanrat E
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: c.eakkapat@hotmail.com.
FAU - Worawichawong, Supanat
AU  - Worawichawong S
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: w.supanat@gmail.com.
FAU - Radinahamed, Piyanuch
AU  - Radinahamed P
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: 
      piyanuch.rad@mahidol.ac.th.
FAU - Sathirapongsasuti, Nuankanya
AU  - Sathirapongsasuti N
AD  - Section for Translational Medicine, Research Center, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Electronic 
      address: nuankanya@gmail.com.
FAU - Nongnuch, Arkom
AU  - Nongnuch A
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: oatega@yahoo.com.
FAU - Assanatham, Montira
AU  - Assanatham M
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: montira_palm@yahoo.com.
FAU - Udomsubpayakul, Umaporn
AU  - Udomsubpayakul U
AD  - Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, 
      Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Electronic 
      address: umaporn.udo@mahidol.ac.th.
FAU - Kitiyakara, Chagriya
AU  - Kitiyakara C
AD  - Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok 10400, Thailand. Electronic address: kitiyakc@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180204
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Cytokines/urine
MH  - Epidermal Growth Factor/*urine
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Glomerulonephritis/complications/physiopathology/*urine
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proteinuria/complications/physiopathology/urine
MH  - ROC Curve
MH  - Remission Induction
OTO - NOTNLM
OT  - Biomarkers
OT  - Epidermal growth factor
OT  - Glomerulonephritis
OT  - Kidney
OT  - Monocyte chemoattractant protein-1
EDAT- 2018/02/08 06:00
MHDA- 2019/04/30 06:00
CRDT- 2018/02/08 06:00
PHST- 2017/09/05 00:00 [received]
PHST- 2018/01/07 00:00 [revised]
PHST- 2018/01/16 00:00 [accepted]
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/02/08 06:00 [entrez]
AID - S1043-4666(18)30015-2 [pii]
AID - 10.1016/j.cyto.2018.01.015 [doi]
PST - ppublish
SO  - Cytokine. 2018 Apr;104:1-7. doi: 10.1016/j.cyto.2018.01.015. Epub 2018 Feb 4.