PMID- 29414665
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 56
DP  - 2018 Mar
TI  - Improving hyperglycemic effect of FGF-21 is associated with alleviating 
      inflammatory state in diabetes.
PG  - 301-309
LID - S1567-5769(18)30048-1 [pii]
LID - 10.1016/j.intimp.2018.01.048 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is accompanied by abnormal glucose metabolism and 
      low-grade chronic inflammation. Fibroblast growth factor 21 (FGF-21) is a novel 
      metabolic regulator and can function as an endocrine hormone to regulate glucose 
      and lipid metabolism. Recently, FGF-21 was found to have anti-inflammatory 
      effect, to our knowledge, the effect of FGF-21 on inflammatory state in diabetes 
      has not been elucidated. Here, we use db/db mice as a Type 2 diabetes model to 
      determine whether FGF-21 alleviates inflammatory state while improves 
      hyperglycemia. Our results demonstrated that FGF-21 not only showed potent long 
      lasting hypoglycemic effect, but also demonstrated strong anti-inflammatory 
      effect in the serum and white adipose tissue. Besides, in vitro experiments, 
      insulin resistance (IR) was induced in 3T3-L1 adipocytes by treating with TNF-alpha. 
      Our results showed that TNF-alpha impaired glucose metabolism of 3T3-L1 adipocytes 
      but FGF-21 repressed gene expression of inflammatory factors caused by IR and 
      consequently improved the glucose metabolism in 3T3-L1 adipocytes. Furthermore, 
      FGF-21 ameliorated glucose uptake of TNF-alpha-induced IR in 3T3-L1 adipocytes by 
      inhibiting NF-kappaB signaling pathway.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Wang, Nan
AU  - Wang N
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China.
FAU - Xu, Tong-Yu
AU  - Xu TY
AD  - Heilongjiang Institute for Food and Drug Control, Harbin 150088, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China.
FAU - Li, Jun-Yan
AU  - Li JY
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China.
FAU - Wang, Yun-Xin
AU  - Wang YX
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China.
FAU - Guo, Xiao-Chen
AU  - Guo XC
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China.
FAU - Li, Si-Ming
AU  - Li SM
AD  - Harbin University of Commerce, Harbin, China.
FAU - Wang, Wen-Fei
AU  - Wang WF
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China; Key Laboratory of Agricultural Biological Functional Gene, 
      Northeast Agricultural University, Harbin 150030, China. Electronic address: 
      wangwenfei@neau.edu.cn.
FAU - Li, De-Shan
AU  - Li DS
AD  - Biopharmaceutical Lab, Life Science college, Northeast Agricultural University, 
      Harbin 150030, China; Key Laboratory of Agricultural Biological Functional Gene, 
      Northeast Agricultural University, Harbin 150030, China. Electronic address: 
      deshanli@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180203
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (NF-kappa B)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fibroblast growth factor 21)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipocytes/*physiology
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - Cell Line
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Fibroblast Growth Factors/*metabolism
MH  - Glucose/*metabolism
MH  - Hyperglycemia
MH  - Inflammation/*metabolism
MH  - Insulin Resistance
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - NF-kappa B/metabolism
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - 3T3-L1 adipocytes
OT  - FGF-21
OT  - Glucose uptake
OT  - Inflammation
OT  - NF-kappaB
EDAT- 2018/02/08 06:00
MHDA- 2018/09/01 06:00
CRDT- 2018/02/08 06:00
PHST- 2017/12/17 00:00 [received]
PHST- 2018/01/25 00:00 [revised]
PHST- 2018/01/31 00:00 [accepted]
PHST- 2018/02/08 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2018/02/08 06:00 [entrez]
AID - S1567-5769(18)30048-1 [pii]
AID - 10.1016/j.intimp.2018.01.048 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2018 Mar;56:301-309. doi: 10.1016/j.intimp.2018.01.048. Epub 
      2018 Feb 3.