PMID- 29416077
OWN - NLM
STAT- MEDLINE
DCOM- 20190816
LR  - 20190816
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Feb 7
TI  - Prefrontal cortex modulates the correlations between brain-derived neurotrophic 
      factor level, serotonin, and the autonomic nervous system.
PG  - 2558
LID - 10.1038/s41598-018-20923-y [doi]
LID - 2558
AB  - Top-down regulation in the human brain and anatomical connections between the 
      prefrontal cortex (PFC) and specific catecholamine-related regions have been 
      well-studied. However, the way in which the PFC modulates downstream 
      neuro-networks in terms of serotonin and the autonomic nervous system (ANS) by 
      variation in the level of brain-derived neurotrophic factor (BDNF) is still 
      unclear. We recruited sixty-seven healthy subjects. Serotonin transporter (SERT) 
      availability was examined by SPECT with [(123)I]ADAM analysis; heart rate 
      variability (HRV) testing was performed, and the BDNF level was measured. The 
      Wisconsin card-sorting test (WCST), which assesses PFC activation, was also 
      conducted. The interactions of BDNF level and SERT availability were significant 
      in relation to the HRV indexes of low frequency, high frequency, total power, and 
      mean heart rate range. Moderate to significant positive correlations between SERT 
      availability and the above-mentioned HRV indexes existed only in subjects with a 
      low BDNF level. Furthermore, in the low BDNF level group, only those with high 
      WCST perseveration errors or low category completions exhibited significant 
      positive correlations between SERT availability and HRV indexes. A lower BDNF 
      level and poorer PFC function might modulate the synergistic effects of 
      serotonergic and ANS systems in order to maintain brain physiological and 
      psychological homeostasis.
FAU - Chang, Wei Hung
AU  - Chang WH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Lee, I Hui
AU  - Lee IH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Chi, Mei Hung
AU  - Chi MH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Lin, Shih-Hsien
AU  - Lin SH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Chen, Kao Chin
AU  - Chen KC
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Chen, Po See
AU  - Chen PS
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Chiu, Nan Tsing
AU  - Chiu NT
AD  - Department of Nuclear Medicine, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Yao, Wei Jen
AU  - Yao WJ
AD  - Department of Nuclear Medicine, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Yang, Yen Kuang
AU  - Yang YK
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan. 
      ykyang@mail.ncku.edu.tw.
AD  - Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou 
      Branch, Yunlin, Taiwan. ykyang@mail.ncku.edu.tw.
AD  - Institute of Behavioral Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan. ykyang@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180207
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
MH  - Adult
MH  - Autonomic Nervous System/*metabolism
MH  - *Brain-Derived Neurotrophic Factor/metabolism/physiology
MH  - Female
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/*metabolism
MH  - Serotonin/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*metabolism
MH  - Tomography, Emission-Computed, Single-Photon/methods
PMC - PMC5803248
COIS- The authors declare no competing interests.
EDAT- 2018/02/09 06:00
MHDA- 2019/08/17 06:00
PMCR- 2018/02/07
CRDT- 2018/02/09 06:00
PHST- 2017/09/22 00:00 [received]
PHST- 2018/01/15 00:00 [accepted]
PHST- 2018/02/09 06:00 [entrez]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2019/08/17 06:00 [medline]
PHST- 2018/02/07 00:00 [pmc-release]
AID - 10.1038/s41598-018-20923-y [pii]
AID - 20923 [pii]
AID - 10.1038/s41598-018-20923-y [doi]
PST - epublish
SO  - Sci Rep. 2018 Feb 7;8(1):2558. doi: 10.1038/s41598-018-20923-y.