PMID- 29416120
OWN - NLM
STAT- MEDLINE
DCOM- 20191018
LR  - 20191018
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 32
IP  - 3
DP  - 2018 Mar
TI  - Relationship of serum immunoglobulin levels to blood pressure and hypertension in 
      an adult population.
PG  - 212-218
LID - 10.1038/s41371-018-0029-2 [doi]
AB  - Evidence suggests long-term chronic inflammation, as the pathological basis of 
      formation and development, plays an important part in atherosclerosis. 
      Immunoglobulins (Igs) provided key information on the humoral immune status. 
      However, few studies have evaluated the correlation between Igs and hypertension 
      and blood pressure (BP) in a general population. We designed a cross-sectional 
      study to evaluate whether serum Ig levels are related to BP and the prevalence of 
      hypertension. About 12,373 participants in Tianjin, China were recruited for this 
      study. Hypertension was diagnosed according to the criteria of the JNC 7 and 
      serum levels of Igs were determined by the immunonephelometric technique. 
      Multiple logistic regression analysis and analysis of covariance were used to 
      assess relationships between serum Ig concentrations and the prevalence of 
      hypertension and BP. The overall prevalence of hypertension was 35.5%. The means 
      (standard deviation) of immunoglobulins [immunoglobulin G (IgG), immunoglobulin E 
      (IgE), immunoglobulin M (IgM), and immunoglobulin A (IgA)] were 1206.0 (249.0) 
      mg/dL, 93.8 (235.4) IU/mL, 105.3 (56.8) mg/dL, and 236.7 (98.1) mg/dL, 
      respectively. The multivariable-adjusted odds ratios (95% confidence interval) of 
      hypertension for the highest immunoglobulins (IgG, IgE, IgM, and IgA) quintile, 
      when compared to the lowest quintile were 1.10 (0.96-1.26), 1.04 (0.91-1.19), 
      0.83 (0.72-0.96), and 1.32 (1.15-1.51), respectively. Decreased IgM and increased 
      IgG and IgA were related to a higher prevalence of hypertension. IgM was 
      negatively correlated with BP, while IgG and IgA were positively correlated with 
      BP.
FAU - Wang, Xiaotong
AU  - Wang X
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Li, Yajun
AU  - Li Y
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Li, Huihui
AU  - Li H
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Gu, Yeqing
AU  - Gu Y
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Song, Yanqi
AU  - Song Y
AD  - Tianjin University of Traditional Chinese Medicine, Tianjin, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Liu, Li
AU  - Liu L
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Meng, Ge
AU  - Meng G
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Yao, Zhanxin
AU  - Yao Z
AD  - Tianjin Institute of Health and Environmental Medicine, Tianjin, China.
FAU - Wu, Hongmei
AU  - Wu H
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Xia, Yang
AU  - Xia Y
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Bao, Xue
AU  - Bao X
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Shi, Hongbin
AU  - Shi H
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Su, Qian
AU  - Su Q
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Fang, Liyun
AU  - Fang L
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Yang, Huijun
AU  - Yang H
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Yu, Fei
AU  - Yu F
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Sun, Shaomei
AU  - Sun S
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Wang, Xing
AU  - Wang X
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Zhou, Ming
AU  - Zhou M
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Jiao, Huanli
AU  - Jiao H
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Jia, Qiyu
AU  - Jia Q
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Song, Kun
AU  - Song K
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Wu, Yuntang
AU  - Wu Y
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Chang, Hong
AU  - Chang H
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China. nkj0809@gmail.com.
FAU - Niu, Kaijun
AU  - Niu K
AD  - Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical 
      University, Tianjin, China. niukaijun@tmu.edu.cn.
AD  - Health Management Centre, Tianjin Medical University General Hospital, Tianjin, 
      China. niukaijun@tmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180207
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Blood Pressure/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*immunology
MH  - Immunoglobulins/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2018/02/09 06:00
MHDA- 2019/10/19 06:00
CRDT- 2018/02/09 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2017/10/16 00:00 [revised]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2019/10/19 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
AID - 10.1038/s41371-018-0029-2 [pii]
AID - 10.1038/s41371-018-0029-2 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2018 Mar;32(3):212-218. doi: 10.1038/s41371-018-0029-2. Epub 
      2018 Feb 7.