PMID- 29416821
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 9
IP  - 2
DP  - 2018 Jan 5
TI  - Dendritic cells loaded with tumor derived exosomes for cancer immunotherapy.
PG  - 2887-2894
LID - 10.18632/oncotarget.20812 [doi]
AB  - Exosomes are vesicles that can be secreted by many types of cell and released 
      into the extracellular space. Studies have found that tumor derived exosomes 
      (TEXs) can promote tumor growth and metastasis, as well as inhibit immune 
      response through transferring their genetic information to the recipient cells. 
      Given their functions in tumor progression, TEXs are considered as promising 
      biomarkers for early detection of human malignancy. Dendritic cells (DCs), a type 
      of antigen presenting cells, can induce tumor-specific T cell immune responses in 
      carcinogenesis. Growing evidences have demonstrated that the matured DCs induced 
      by TEXs exhibit enhanced anti-tumor effects that may be applied for cancer 
      immunotherapy. Thus in this review, according to the previous studies, we 
      summarized the effects of DCs loaded with TEXs in cancer immunotherapy.
FAU - Liu, Hongyu
AU  - Liu H
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Chen, Ling
AU  - Chen L
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Peng, Yaojun
AU  - Peng Y
AD  - Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Yu, Songyan
AU  - Yu S
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Liu, Jialin
AU  - Liu J
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Wu, Liangliang
AU  - Wu L
AD  - Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Zhang, Lijun
AU  - Zhang L
AD  - Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Wu, Qiyan
AU  - Wu Q
AD  - Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Chang, Xin
AU  - Chang X
AD  - Department of Clinical Laboratory, Weihai Municipal Hospital, Weihai 264200, 
      Shandong, China.
FAU - Yu, Xinguang
AU  - Yu X
AD  - Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Liu, Tianyi
AU  - Liu T
AD  - Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170911
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5788689
OTO - NOTNLM
OT  - dendritic cells
OT  - immunotherapy
OT  - tumor derived exosomes
COIS- CONFLICTS OF INTEREST None.
EDAT- 2018/02/09 06:00
MHDA- 2018/02/09 06:01
PMCR- 2018/01/05
CRDT- 2018/02/09 06:00
PHST- 2016/10/21 00:00 [received]
PHST- 2017/04/29 00:00 [accepted]
PHST- 2018/02/09 06:00 [entrez]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2018/02/09 06:01 [medline]
PHST- 2018/01/05 00:00 [pmc-release]
AID - 20812 [pii]
AID - 10.18632/oncotarget.20812 [doi]
PST - epublish
SO  - Oncotarget. 2017 Sep 11;9(2):2887-2894. doi: 10.18632/oncotarget.20812. 
      eCollection 2018 Jan 5.