PMID- 29419858
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20180605
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 35
IP  - 1
DP  - 2018 Feb 10
TI  - [Origin and morphological features of small supernumerary marker chromosomes in 
      Turner syndrome].
PG  - 43-46
LID - 10.3760/cma.j.issn.1003-9406.2018.01.009 [doi]
AB  - OBJECTIVE To explore the origin and morphological features of small supernumerary 
      marker chromosomes (sSMCs) in Turner syndrome. METHODS For 5 cases of Turner 
      syndrome with a sSMC identified by conventional G-banding, dual-color 
      fluorescence in situ hybridization (FISH) was applied to explore their origin and 
      morphological features. RESULTS Among the 5 cases, 3 have derived from the X 
      chromosome, which included 2 ring chromosomes and 1 centric minute. For the 2 
      sSMCs derived from the Y chromosome, 1 was ring or isodicentric chromosome, while 
      the other was an isodicentric chromosome. CONCLUSION The sSMCs found in Turner 
      syndrome have almost all derived from sex chromosomes. The majority of sSMCs 
      derived from the X chromosome will form ring chromosomes, while a minority will 
      form centric minute. While most sSMC derived from Y chromosome may exist as 
      isodicentric chromosomes, and a small number may exist as rings. For Turner 
      syndrome patients with sSMCs, dual-color FISH may be used to delineate their 
      origins to facilitate genetic counseling and selection of clinical regime.
FAU - Liu, Nan
AU  - Liu N
AD  - Tianjin Children's Hospital, Tianjin 300134, China. Email: tjln002@vip.sina.com.
FAU - Tong, Tong
AU  - Tong T
FAU - Chen, Yue
AU  - Chen Y
FAU - Chen, Yanling
AU  - Chen Y
FAU - Cai, Chunquan
AU  - Cai C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Centromere/genetics
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Aberrations
MH  - Chromosome Painting/methods
MH  - Chromosomes, Human, X/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Female
MH  - Humans
MH  - *Ring Chromosomes
MH  - Turner Syndrome/*genetics
EDAT- 2018/02/09 06:00
MHDA- 2018/06/06 06:00
CRDT- 2018/02/09 06:00
PHST- 2018/02/09 06:00 [entrez]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
AID - 940635009 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2018.01.009 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Feb 10;35(1):43-46. doi: 
      10.3760/cma.j.issn.1003-9406.2018.01.009.