PMID- 29420702
OWN - NLM
STAT- MEDLINE
DCOM- 20190626
LR  - 20190626
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 28
IP  - 4
DP  - 2018 Apr 1
TI  - Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin.
PG  - 1516-1531
LID - 10.1093/cercor/bhy018 [doi]
AB  - Radial migration of cortical projection neurons is a prerequisite for shaping a 
      distinct multilayered cerebral cortex during mammalian corticogenesis. Members of 
      Rab GTPases family were reported to regulate radial migration. Here, in vivo 
      conditional knockout or in utero knockdown (KD) of Rab23 in mice neocortex causes 
      aberrant polarity and halted migration of cortical projection neurons. Further 
      investigation of the underlying mechanism reveals down-regulation of N-cadherin 
      in the Rab23-deficient neurons, which is a cell adhesion protein previously known 
      to modulate radial migration. (Shikanai M, Nakajima K, Kawauchi T. 2011. 
      N-cadherin regulates radial glial fiber-dependent migration of cortical 
      locomoting neurons. Commun Integr Biol. 4:326-330.) Interestingly, 
      pharmacological inhibition of extracellular signal-regulated kinases (ERK1/2) 
      also decreases the expression of N-cadherin, implicating an upstream effect of 
      ERK1/2 on N-cadherin and also suggesting a link between Rab23 and ERK1/2. Further 
      biochemical studies show that silencing of Rab23 impedes activation of ERK1/2 via 
      perturbed platelet-derived growth factor-alpha (PDGFRalpha) signaling. Restoration of 
      the expression of Rab23 or N-cadherin in Rab23-KD neurons could reverse neuron 
      migration defects, indicating that Rab23 modulates migration through N-cadherin. 
      These studies suggest that cortical neuron migration is mediated by a molecular 
      hierarchy downstream of Rab23 via N-cadherin.
FAU - Hor, Catherine H H
AU  - Hor CHH
AD  - Neuroscience Academic Clinical Programme, Duke-NUS Medical School, Singapore 
      169857, Singapore.
AD  - Department of Research, National Neuroscience Institute, Singapore 308433, 
      Singapore.
FAU - Goh, Eyleen L K
AU  - Goh ELK
AD  - Neuroscience Academic Clinical Programme, Duke-NUS Medical School, Singapore 
      169857, Singapore.
AD  - Department of Research, National Neuroscience Institute, Singapore 308433, 
      Singapore.
AD  - Department of Physiology, Yong Loo Lin School of Medicine, National University of 
      Singapore, 8 Medical Drive, Singapore 117597, Singapore.
AD  - KK Research Center, KK Women's and Children's Hospital, Singapore 229899, 
      Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Cadherins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Mtap2 protein, mouse)
RN  - 0 (Nestin)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Transcription Factors)
RN  - 0 (empty spiracles homeobox proteins)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
RN  - EC 3.6.1.- (Rab23 protein, mouse)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Cadherins/genetics/*metabolism
MH  - Cell Movement/*genetics
MH  - Cerebral Cortex/*cytology/embryology/growth & development
MH  - Embryo, Mammalian
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Homeodomain Proteins/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Microtubule-Associated Proteins/metabolism
MH  - Nestin/metabolism
MH  - Neurons/*physiology
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Receptor, Platelet-Derived Growth Factor alpha/metabolism
MH  - Signal Transduction/genetics
MH  - Time Factors
MH  - Transcription Factors/metabolism
MH  - rab GTP-Binding Proteins/genetics/*metabolism
PMC - PMC6093454
EDAT- 2018/02/09 06:00
MHDA- 2019/06/27 06:00
PMCR- 2018/02/06
CRDT- 2018/02/09 06:00
PHST- 2017/04/11 00:00 [received]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2019/06/27 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
PHST- 2018/02/06 00:00 [pmc-release]
AID - 4840630 [pii]
AID - bhy018 [pii]
AID - 10.1093/cercor/bhy018 [doi]
PST - ppublish
SO  - Cereb Cortex. 2018 Apr 1;28(4):1516-1531. doi: 10.1093/cercor/bhy018.