PMID- 29420707
OWN - NLM
STAT- MEDLINE
DCOM- 20190603
LR  - 20190603
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 20
IP  - 10
DP  - 2018 Oct 1
TI  - Association of left ventricular late gadolinium enhancement with left atrial low 
      voltage areas in patients with atrial fibrillation.
PG  - 1606-1611
LID - 10.1093/europace/euy013 [doi]
AB  - AIMS: Presence of late gadolinium enhancement (LGE) is related to adverse 
      cardiovascular outcome. Many patients suffering from atrial fibrillation (AF) 
      undergo cardiovascular magnetic resonance (CMR) imaging prior to ablation. Since 
      quantification of atrial fibrosis still lacks reproducibility, we sought to 
      investigate risk factors for the presence of left ventricular (LV)-LGE and a 
      possible correlation between ventricular fibrosis as defined by positive LGE and 
      pathological atrial voltage maps evaluated by 3D mapping systems. METHODS AND 
      RESULTS: Between May 2015 and January 2017, 241 patients with AF (73% persistent 
      AF, 71% male, mean age 62.8 +/- 10.1 years, Redo procedure in 24%, AF history 
      4.5 +/- 5.2 years) underwent CMR including LV LGE prior to pulmonary vein (PV) 
      isolation at Heart Center Leipzig. Depending on CMR results, two groups were 
      separated: 'LV-LGE negative' (Group A, n = 197, 82%) and 'LV-LGE positive' (Group 
      B, n = 44, 18%). To identify low voltage areas (LVA), a 3D electro-anatomic map 
      was created during PV isolation. Multivariate analysis revealed male gender [odds 
      ratio (OR) 7.6, 95% confidence interval (95% CI) 2.4-23.9, P = 0.001] and an 
      increased CHA2DS2VASc Score (OR 1.6, 95% CI 1.2-2.2, P = 0.004) as significantly 
      associated with LV-LGE. Impaired left ventricular ejection fraction, LV 
      dilatation, larger LA size and, enlarged septum diameter occurred significantly 
      more often in the 'LGE positive' group. Low voltage areas were detected in 83 
      patients overall (34%): Group A: n = 64/197 (33%), Group B: n = 19/44 (43%) 
      (P = 0.177). CONCLUSION: Male gender and high CHA2DS2VASc Score are significantly 
      associated with presence of LV-LGE, but LV-LGE is not associated with left atrial 
      LVA.
FAU - Stegmann, Clara
AU  - Stegmann C
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Jahnke, Cosima
AU  - Jahnke C
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Paetsch, Ingo
AU  - Paetsch I
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Hilbert, Sebastian
AU  - Hilbert S
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Arya, Arash
AU  - Arya A
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Bollmann, Andreas
AU  - Bollmann A
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Hindricks, Gerhard
AU  - Hindricks G
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
FAU - Sommer, Philipp
AU  - Sommer P
AD  - Department of Electrophysiology, Heart Center - University of Leipzig, 
      Strumpellstr. 39, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*diagnostic imaging/epidemiology/surgery
MH  - Catheter Ablation
MH  - Comorbidity
MH  - Contrast Media
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Gadolinium DTPA
MH  - Heart Atria/*diagnostic imaging
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Sex Factors
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/epidemiology
EDAT- 2018/02/09 06:00
MHDA- 2019/06/04 06:00
CRDT- 2018/02/09 06:00
PHST- 2017/08/29 00:00 [received]
PHST- 2018/01/14 00:00 [accepted]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2019/06/04 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
AID - 4840602 [pii]
AID - 10.1093/europace/euy013 [doi]
PST - ppublish
SO  - Europace. 2018 Oct 1;20(10):1606-1611. doi: 10.1093/europace/euy013.