PMID- 29420916
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20200930
IS  - 1208-6002 (Electronic)
IS  - 0829-8211 (Linking)
VI  - 96
IP  - 5
DP  - 2018 Oct
TI  - Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via 
      estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
PG  - 672-681
LID - 10.1139/bcb-2017-0209 [doi]
AB  - Rutin, a flavonoid glycoside, has been reported to exert neuroprotective effects. 
      Loss of endogenous estrogen and dysregulation of the estrogen receptor (ER) 
      signaling pathway are associated with the increased risk of stroke in women after 
      menopause. This study was performed to investigate whether rutin could protect 
      against cerebral ischemia by modulating the ER pathway. Ovariectomized (OVX) rats 
      were given intraperitoneal injections of vehicle (dimethyl sulfoxide), rutin (100 
      mg/kg body mass) or 17beta-estradiol (100 mug/kg body mass) for 5 consecutive days. 
      Then, the rats were subjected to middle cerebral artery occlusion (MCAO) for 1 h 
      followed by a 24 h reperfusion to establish the cerebral ischemia-reperfusion 
      (I/R) injury. We found that rutin improved the sensorimotor performance and 
      recognition memory of rats subjected to I/R, decreased the infarct size, and 
      attenuated neuron loss. Rutin treatment also increased the levels of ERalpha, ERbeta, 
      brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), tropomyosin 
      receptor kinase A (TrkA), TrkB, and phospho-cAMP-responsive element binding 
      protein (p-CREB) in rat hippocampus and cerebral cortex. The protective effects 
      of rutin were comparable to that of 17beta-estradiol, and were partially blocked by 
      ICI182780, an ER antagonist. The above results suggest that rutin preconditioning 
      ameliorates cerebral I/R injury in OVX rats through ER-mediated BDNF-TrkB and 
      NGF-TrkA signaling.
FAU - Liu, Hong
AU  - Liu H
AD  - a Department of Pathology and Pathophysiology, School of Basic Medical Sciences, 
      Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang 
      Province, P.R. China.
AD  - b Postdoctoral Program, Heilongjiang University of Chinese Medicine, Harbin 
      150040, Heilongjiang Province, P.R. China.
AD  - c Key Laboratory of Education Ministry for Myocardial Ischemia, Harbin Medical 
      University, Harbin 150081, Heilongjiang Province, P.R. China.
FAU - Zhong, Lili
AU  - Zhong L
AD  - b Postdoctoral Program, Heilongjiang University of Chinese Medicine, Harbin 
      150040, Heilongjiang Province, P.R. China.
AD  - d Department of Pathology, The First Affiliated Hospital of Heilongjiang 
      University of Chinese Medicine, Harbin 150001, Heilongjiang Province, P.R. China.
FAU - Zhang, Yuwei
AU  - Zhang Y
AD  - e Department of Physiology, School of Basic Medical Sciences, Heilongjiang 
      University of Chinese Medicine, Harbin 150040, Heilongjiang Province, P.R. China.
FAU - Liu, Xuewei
AU  - Liu X
AD  - f Department of Neuropharmacology, Institute of Medicine and Pharmacy, Qiqihar 
      Medical University, Qiqihar 161006, Heilongjiang Province, P.R. China.
FAU - Li, Ji
AU  - Li J
AD  - g Department of Formulaology, School of Basic Medical Sciences, Heilongjiang 
      University of Chinese Medicine, Harbin 150040, Heilongjiang Province, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180208
PL  - Canada
TA  - Biochem Cell Biol
JT  - Biochemistry and cell biology = Biochimie et biologie cellulaire
JID - 8606068
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Estrogen)
RN  - 5G06TVY3R7 (Rutin)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Nerve Growth Factor/*metabolism
MH  - *Ovariectomy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkA/*metabolism
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Estrogen/*metabolism
MH  - *Reperfusion Injury/drug therapy/metabolism/pathology
MH  - Rutin/*pharmacology
MH  - Signal Transduction/*drug effects
OTO - NOTNLM
OT  - 17beta-estradiol
OT  - I/R injury
OT  - MCAO
OT  - OLAC
OT  - dommage d'I/R
OT  - neuroprotection
OT  - rutin
OT  - rutine
EDAT- 2018/02/09 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/02/09 06:00
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
AID - 10.1139/bcb-2017-0209 [doi]
PST - ppublish
SO  - Biochem Cell Biol. 2018 Oct;96(5):672-681. doi: 10.1139/bcb-2017-0209. Epub 2018 
      Feb 8.