PMID- 29421170
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1872-9452 (Electronic)
IS  - 0098-2997 (Linking)
VI  - 61
DP  - 2018 Jun
TI  - Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm.
PG  - 31-40
LID - S0098-2997(18)30002-5 [pii]
LID - 10.1016/j.mam.2018.01.007 [doi]
AB  - Polyphenols are bioactives claimed to be responsible for some of the health 
      benefits provided by fruit and vegetables. It is currently accepted that the 
      bioactivities of polyphenols can be mostly ascribed to their interactions with 
      proteins and lipids. Such interactions can affect cell oxidant production and 
      cell signaling, and explain in part the ability of polyphenols to promote health. 
      EC can modulate redox sensitive signaling by: i) defining the extent of oxidant 
      levels that can modify cell signaling, function, and fate, e.g. regulating 
      enzymes that generate superoxide, hydrogen peroxide and nitric oxide; or ii) 
      regulating the activation of transcription factors sensible to oxidants. The 
      latter includes the regulation of the nuclear factor E2-related factor 2 (Nfr2) 
      pathway, which in turn can promote the synthesis of antioxidant defenses, and of 
      nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway, 
      which mediates the expression of oxidants generating enzymes, as well as proteins 
      not involved in redox reactions. In summary, a significant amount of data 
      vindicates the participation of EC in redox regulated signaling pathways. 
      Progress in the understanding of the molecular mechanisms involved in EC 
      biological actions will help to define recommendations in terms of which fruit 
      and vegetables are healthier and the amounts necessary to provide health effects.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Fraga, Cesar G
AU  - Fraga CG
AD  - Fisicoquimica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 
      Buenos Aires, Argentina; Instituto de Bioquimica y Medicina Molecular (IBIMOL), 
      Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina; Department of 
      Nutrition, University of California, Davis, USA. Electronic address: 
      cfraga@ffyb.uba.ar.
FAU - Oteiza, Patricia I
AU  - Oteiza PI
AD  - Department of Nutrition, University of California, Davis, USA; Department of 
      Environmental Toxicology, University of California, Davis, USA.
FAU - Galleano, Monica
AU  - Galleano M
AD  - Fisicoquimica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 
      Buenos Aires, Argentina; Instituto de Bioquimica y Medicina Molecular (IBIMOL), 
      Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20180210
PL  - England
TA  - Mol Aspects Med
JT  - Molecular aspects of medicine
JID - 7603128
RN  - 0 (Antioxidants)
RN  - 0 (Phytochemicals)
RN  - 8R1V1STN48 (Catechin)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Catechin/chemistry/*metabolism
MH  - Humans
MH  - Oxidation-Reduction
MH  - Phytochemicals/chemistry/*metabolism
MH  - Plants/*metabolism
MH  - *Signal Transduction
OTO - NOTNLM
OT  - Antioxidants
OT  - Flavonoid
OT  - NADPH-oxidase
OT  - NF-kappaB
OT  - Nitric oxide
OT  - Nrf2
OT  - Oxygen radicals
OT  - Polyphenols
OT  - Superoxide
EDAT- 2018/02/09 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/02/09 06:00
PHST- 2018/01/04 00:00 [received]
PHST- 2018/01/25 00:00 [revised]
PHST- 2018/01/25 00:00 [accepted]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
AID - S0098-2997(18)30002-5 [pii]
AID - 10.1016/j.mam.2018.01.007 [doi]
PST - ppublish
SO  - Mol Aspects Med. 2018 Jun;61:31-40. doi: 10.1016/j.mam.2018.01.007. Epub 2018 Feb 
      10.