PMID- 29421401
OWN - NLM
STAT- MEDLINE
DCOM- 20181228
LR  - 20240216
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 113
DP  - 2018 Apr
TI  - Association between prenatal exposure to multiple insecticides and child body 
      weight and body composition in the VHEMBE South African birth cohort.
PG  - 122-132
LID - S0160-4120(17)31150-9 [pii]
LID - 10.1016/j.envint.2018.01.016 [doi]
AB  - BACKGROUND: Pregnant women may be co-exposed to multiple insecticides in regions 
      where both pyrethroids and dichlorodiphenyltrichloroethane (DDT) are used for 
      indoor residual spraying (IRS) for malaria control. Despite the potential for 
      adverse effects on offspring, there are few studies in areas where IRS is 
      currently used and little is known about the effects of pyrethroids on children's 
      health. METHODS: We investigated the relationship between concentrations of four 
      urinary pyrethroid metabolites in urine and organochlorine pesticide 
      concentrations in maternal blood collected near delivery on body weight and body 
      composition among children </=2 years old participating in the prospective South 
      Africa VHEMBE birth cohort (N = 708). We used measurements of length/height and 
      weight collected at 1 and 2 years of age to calculate body mass index 
      (BMI)-for-age, weight-for-age, and weight-for-height z-scores based on World 
      Health Organization standards. We fit separate single-pollutant mixed effects 
      models for each exposure of interest and also stratified by sex. We also fit all 
      analyte concentrations jointly by using a Bayesian kernel machine regression 
      (BKMR) statistical method to assess variable importance of each analyte and to 
      explore the potential for joint effects of the multiple exposures. RESULTS: 
      Single-pollutant linear mixed effects models showed that, among girls only, 
      p,p'-DDT was associated with higher BMI-for-age (adjusted [a]beta = 0.22 [95% CI: 
      0.10, 0.35]; sex interaction p-value = 0.001), weight-for-height (abeta = 0.22 [95% 
      CI: 0.09, 0.34]; sex interaction p-value = 0.002), and weight-for-age (abeta = 0.17 
      [95% CI: 0.05, 0.29], sex interaction p-value = 0.01). Although single-pollutant 
      models suggested that p,p'-DDT and dichlorodiphenyldichloroethylene (p,p'-DDE) 
      were also associated with these outcomes in girls, p,p'-DDE was no longer 
      associated in multi-pollutant models with BKMR. The pyrethroid metabolites 
      cis-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylicacid (cis-DBCA) and 
      trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA) 
      were inversely related to BMI-for-age and weight-for-height overall; however, 
      results suggested that weight-for-age and weight-for-height associations for 
      trans-DCCA (sex interaction p-value(weight-for-age) = 0.02; 
      p-value(weight-for-height) = 0.13) and cis-DCCA (sex interaction 
      p-value(weight-for-age) = 0.02; p-value(weight-for-height) = 0.08) were strongest 
      and most consistent in boys relative to girls. BKMR also revealed joint effects 
      from the chemical mixture. For instance, with increased concentrations of 
      p,p'-DDE, the negative exposure-response relationship for cis-DBCA on BMI-for-age 
      became steeper. CONCLUSIONS: Our single-pollutant and multi-pollutant model 
      results show that maternal serum p,p'-DDT concentration was consistently and 
      positively associated with body composition and body weight in young girls and 
      that maternal urinary pyrethroid metabolite concentrations (particularly cis-DBCA 
      and trans-DCCA) were negatively associated with body weight and body composition 
      in young boys. Joint effects of the insecticide exposure mixture were also 
      apparent, underscoring the importance of using advanced statistical methods to 
      examine the health effects of chemical mixtures.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Coker, Eric
AU  - Coker E
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, 1995 University Ave, Berkeley, CA, 
      USA. Electronic address: eric.coker@berkeley.edu.
FAU - Chevrier, Jonathan
AU  - Chevrier J
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill 
      University, 1020 Pine Avenue West, Room 42, Montreal, Quebec, Canada. Electronic 
      address: jonathan.chevrier@mcgill.ca.
FAU - Rauch, Stephen
AU  - Rauch S
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, 1995 University Ave, Berkeley, CA, 
      USA. Electronic address: srauch@berkeley.edu.
FAU - Bradman, Asa
AU  - Bradman A
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, 1995 University Ave, Berkeley, CA, 
      USA. Electronic address: abradman@berkeley.edu.
FAU - Obida, Muvhulawa
AU  - Obida M
AD  - School of Health Systems and Public Health (SHSPH), University of Pretoria 
      Institute for Sustainable Malaria Control (UP ISMC), MRC Collaborating Centre for 
      Malaria Research, CMEG Laboratory, University of Pretoria, Hatfield Campus, Floor 
      3, NWII Building, Pretoria 0028, South Africa.
FAU - Crause, Madelein
AU  - Crause M
AD  - School of Health Systems and Public Health (SHSPH), University of Pretoria 
      Institute for Sustainable Malaria Control (UP ISMC), MRC Collaborating Centre for 
      Malaria Research, CMEG Laboratory, University of Pretoria, Hatfield Campus, Floor 
      3, NWII Building, Pretoria 0028, South Africa.
FAU - Bornman, Riana
AU  - Bornman R
AD  - School of Health Systems and Public Health (SHSPH), University of Pretoria 
      Institute for Sustainable Malaria Control (UP ISMC), MRC Collaborating Centre for 
      Malaria Research, CMEG Laboratory, University of Pretoria, Hatfield Campus, Floor 
      3, NWII Building, Pretoria 0028, South Africa. Electronic address: 
      Riana.Bornman@up.ac.za.
FAU - Eskenazi, Brenda
AU  - Eskenazi B
AD  - Center for Environmental Research and Children's Health (CERCH), School of Public 
      Health, University of California at Berkeley, 1995 University Ave, Berkeley, CA, 
      USA. Electronic address: eskenazi@berkeley.edu.
LA  - eng
GR  - R01 ES020360/ES/NIEHS NIH HHS/United States
GR  - R25 TW009338/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20180206
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Insecticides)
SB  - IM
EIN - Environ Int. 2020 Oct;143:106070. PMID: 32861474
MH  - Body Composition/*drug effects
MH  - Body Weight/*drug effects
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Insecticides/*toxicity
MH  - Maternal Exposure/*statistics & numerical data
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology
MH  - Prospective Studies
MH  - South Africa/epidemiology
PMC - PMC5866210
MID - NIHMS939806
OTO - NOTNLM
OT  - DDE
OT  - DDT
OT  - Indoor residual spraying
OT  - Prenatal
OT  - Pyrethroids
COIS- All authors report no competing interests.
EDAT- 2018/02/09 06:00
MHDA- 2018/12/29 06:00
PMCR- 2019/04/01
CRDT- 2018/02/09 06:00
PHST- 2017/07/29 00:00 [received]
PHST- 2017/11/21 00:00 [revised]
PHST- 2018/01/19 00:00 [accepted]
PHST- 2018/02/09 06:00 [pubmed]
PHST- 2018/12/29 06:00 [medline]
PHST- 2018/02/09 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - S0160-4120(17)31150-9 [pii]
AID - 10.1016/j.envint.2018.01.016 [doi]
PST - ppublish
SO  - Environ Int. 2018 Apr;113:122-132. doi: 10.1016/j.envint.2018.01.016. Epub 2018 
      Feb 6.