PMID- 29421527 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1665-1146 (Electronic) IS - 0539-6115 (Linking) VI - 72 IP - 5 DP - 2015 Sep-Oct TI - Retinoblastoma in Mexico: part I. A review of general knowledge of the disease, diagnosis, and management. PG - 299-306 LID - S1665-1146(15)00171-9 [pii] LID - 10.1016/j.bmhimx.2015.09.001 [doi] AB - This is the first of a two-part review that aims to report the current knowledge of retinoblastoma (Rb) and its implications in Mexico (including the authors' experience at the leading Rb centers), identify the gaps in practice, and propose solutions to improve diagnosis, treatment, and patient uptake. In this first part, general knowledge of Rb diagnosis and management is summarized with a focus on the latest advances in chemotherapy. A general review of peer-reviewed literature of Rb was conducted on PubMed. Key findings were summarized. Provided there is early detection and referral of patients followed by appropriate conservative management, Rb is curable. In developed countries, the primary treatment outcome is ocular salvage with sight preservation. Advanced chemotherapeutic options such as intra-arterial and intravitreal chemotherapy can now save even the most advanced tumors. Advances in Rb therapy are generally limited to developed countries. The implications in Mexico, of the findings from this review will be discussed in Part 2, which will be a comprehensive situational analysis of the state of Rb programming in Mexico, including a review of current demographic data available from hospitals that have Rb programs or treat Rb. CI - Copyright (c) 2015 Hospital Infantil de Mexico Federico Gomez. Publicado por Masson Doyma Mexico S.A. All rights reserved. FAU - Lansingh, Van C AU - Lansingh VC AD - Instituto Mexicano de Oftalmologia, Queretaro , Queretaro, Mexico; Help Me See, New York, NY, USA; Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA. FAU - Eckert, Kristen A AU - Eckert KA AD - Independent Public Health Consultant, Tapachula, Chiapas, Mexico. FAU - Haik, Barrett G AU - Haik BG AD - Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA. FAU - Phillipps, Blanca X AU - Phillipps BX AD - Department of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN, USA. FAU - Bosch-Canto, Vanessa AU - Bosch-Canto V AD - Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Leal-Leal, Carlos AU - Leal-Leal C AD - Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Ramirez-Ortiz, Marco A AU - Ramirez-Ortiz MA AD - Department of Ophthalmology, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico. Electronic address: marco@unam.mx. LA - eng PT - Journal Article DEP - 20151026 PL - Mexico TA - Bol Med Hosp Infant Mex JT - Boletin medico del Hospital Infantil de Mexico JID - 0414106 OTO - NOTNLM OT - Diagnostico temprano del cancer OT - Disease management OT - Early cancer detection OT - Epidemiology OT - Epidemiologia OT - Manejo de enfermedad OT - Retinoblastoma EDAT- 2015/01/01 00:00 MHDA- 2015/01/01 00:01 CRDT- 2018/02/09 06:00 PHST- 2015/05/27 00:00 [received] PHST- 2015/08/27 00:00 [revised] PHST- 2015/09/04 00:00 [accepted] PHST- 2018/02/09 06:00 [entrez] PHST- 2015/01/01 00:00 [pubmed] PHST- 2015/01/01 00:01 [medline] AID - S1665-1146(15)00171-9 [pii] AID - 10.1016/j.bmhimx.2015.09.001 [doi] PST - ppublish SO - Bol Med Hosp Infant Mex. 2015 Sep-Oct;72(5):299-306. doi: 10.1016/j.bmhimx.2015.09.001. Epub 2015 Oct 26.