PMID- 29421993 OWN - NLM STAT- MEDLINE DCOM- 20200221 LR - 20200221 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 22 IP - 10 DP - 2019 Oct TI - Zinc supplementation does not influence serum levels of VEGF, BDNF, and NGF in diabetic retinopathy patients: a randomized controlled clinical trial. PG - 718-724 LID - 10.1080/1028415X.2018.1436236 [doi] AB - Objectives: This study was aimed to evaluate the effects of zinc (Zn) supplementation on serum levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in patients with diabetic retinopathy (DR). Methods: In this randomized clinical trial, 50 patients with DR were allocated into the Zn (n = 25) and placebo (n = 25) groups to receive 30 mg Zn gluconate or maltose dextrin per day, respectively, for three months. Metabolic parameters and blood pressure were measured. Serum levels of Zn were assessed by atomic absorption spectrophotometry and serum levels of VEGF, BDNF and NGF by ELISA. Results: Forty-five patients completed the intervention. Levels of VEGF, BDNF and NGF were not affected by the Zn supplementation. Levels of VEGF correlated negatively with levels of Zn and positively with BDNF and NGF. There was also a positive correlation between BDNF and NGF. Serum levels of VEGF, BDNF and NGF were negatively correlated with serum levels of the diabetic parameters measured. Conclusions: Strong positive relationship between the growth factors and their inverse association with metabolic factors is possibly suggesting the contribution of these factors in the pathogenesis of DR through acting in a same biological pathway. FAU - Kheirouri, Sorayya AU - Kheirouri S AD - Department of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran. FAU - Naghizadeh, Siamak AU - Naghizadeh S AD - Department of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran. FAU - Alizadeh, Mohammad AU - Alizadeh M AD - Department of Nutrition, Tabriz University of Medical Sciences , Tabriz , Iran. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180208 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (NGF protein, human) RN - 0 (VEGFA protein, human) RN - 0 (Vascular Endothelial Growth Factor A) RN - 7171WSG8A2 (BDNF protein, human) RN - 9061-61-4 (Nerve Growth Factor) RN - J41CSQ7QDS (Zinc) SB - IM MH - Brain-Derived Neurotrophic Factor/*blood MH - Diabetic Retinopathy/*blood/*drug therapy MH - Female MH - Humans MH - Male MH - Middle Aged MH - Nerve Growth Factor/*blood MH - Treatment Outcome MH - Vascular Endothelial Growth Factor A/*blood MH - Zinc/*therapeutic use OTO - NOTNLM OT - BDNF OT - Diabetic retinopathy OT - NGF OT - VEGF OT - Zinc EDAT- 2018/02/10 06:00 MHDA- 2020/02/23 06:00 CRDT- 2018/02/10 06:00 PHST- 2018/02/10 06:00 [pubmed] PHST- 2020/02/23 06:00 [medline] PHST- 2018/02/10 06:00 [entrez] AID - 10.1080/1028415X.2018.1436236 [doi] PST - ppublish SO - Nutr Neurosci. 2019 Oct;22(10):718-724. doi: 10.1080/1028415X.2018.1436236. Epub 2018 Feb 8.