PMID- 29422410
OWN - NLM
STAT- MEDLINE
DCOM- 20181220
LR  - 20220129
IS  - 1879-3096 (Electronic)
IS  - 0167-7799 (Linking)
VI  - 36
IP  - 4
DP  - 2018 Apr
TI  - Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting 
      Perspective.
PG  - 457-472
LID - S0167-7799(18)30024-6 [pii]
LID - 10.1016/j.tibtech.2018.01.003 [doi]
AB  - Neurovascular dysfunction is a central process in the pathogenesis of stroke and 
      most neurodegenerative diseases, including Alzheimer's disease. The multicellular 
      neurovascular unit (NVU) combines the neural, vascular and extracellular matrix 
      (ECM) components in an important interface whose correct functioning is critical 
      to maintain brain health. Tissue engineering is now offering new tools and 
      insights to advance our understanding of NVU function. Here, we review how the 
      use of novel biomaterials to mimic the mechanical and functional cues of the ECM, 
      coupled with precisely layered deposition of the different cells of the NVU 
      through 3D bioprinting, is revolutionising the study of neurovascular function 
      and dysfunction.
CI  - Crown Copyright (c) 2018. Published by Elsevier Ltd. All rights reserved.
FAU - Potjewyd, Geoffrey
AU  - Potjewyd G
AD  - Division of Neuroscience and Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 
      Manchester Academic Health Science Centre, Manchester M13 9PL, UK; Division of 
      Evolution and Genomic Sciences, School of Medical Sciences, Faculty of Biology, 
      Medicine and Health, The University of Manchester, Manchester M13 9PL, UK; 
      Manchester Institute of Biotechnology, The University of Manchester, Manchester 
      M1 7DN, UK. Electronic address: http://twitter.com/@Geoff3P.
FAU - Moxon, Samuel
AU  - Moxon S
AD  - Division of Neuroscience and Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 
      Manchester Academic Health Science Centre, Manchester M13 9PL, UK. Electronic 
      address: http://twitter.com/@DrSamMoxon.
FAU - Wang, Tao
AU  - Wang T
AD  - Division of Evolution and Genomic Sciences, School of Medical Sciences, Faculty 
      of Biology, Medicine and Health, The University of Manchester, Manchester M13 
      9PL, UK.
FAU - Domingos, Marco
AU  - Domingos M
AD  - Manchester Institute of Biotechnology, The University of Manchester, Manchester 
      M1 7DN, UK.
FAU - Hooper, Nigel M
AU  - Hooper NM
AD  - Division of Neuroscience and Experimental Psychology, School of Biological 
      Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 
      Manchester Academic Health Science Centre, Manchester M13 9PL, UK. Electronic 
      address: http://twitter.com/@HooperLabManc.
LA  - eng
GR  - MR/L023784/1/MRC_/Medical Research Council/United Kingdom
GR  - NC/K001744/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction 
      of Animals in Research/United Kingdom
GR  - PG/12/31/29527/BHF_/British Heart Foundation/United Kingdom
GR  - MR/L023784/2/MRC_/Medical Research Council/United Kingdom
GR  - MC_PC_16033/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20180206
PL  - England
TA  - Trends Biotechnol
JT  - Trends in biotechnology
JID - 8310903
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*chemistry
MH  - *Bioprinting
MH  - Brain Diseases/therapy
MH  - Extracellular Matrix/chemistry
MH  - Humans
MH  - Hydrogels/chemistry
MH  - Models, Animal
MH  - Neuroglia/chemistry
MH  - Neurons/chemistry
MH  - *Printing, Three-Dimensional
MH  - *Tissue Engineering
OTO - NOTNLM
OT  - 3D bioprinting
OT  - biofabrication
OT  - bioinks
OT  - disease modelling
OT  - hydrogel matrices
OT  - neurovascular unit
OT  - tissue engineering
EDAT- 2018/02/10 06:00
MHDA- 2018/12/21 06:00
CRDT- 2018/02/10 06:00
PHST- 2017/11/10 00:00 [received]
PHST- 2018/01/05 00:00 [revised]
PHST- 2018/01/08 00:00 [accepted]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/12/21 06:00 [medline]
PHST- 2018/02/10 06:00 [entrez]
AID - S0167-7799(18)30024-6 [pii]
AID - 10.1016/j.tibtech.2018.01.003 [doi]
PST - ppublish
SO  - Trends Biotechnol. 2018 Apr;36(4):457-472. doi: 10.1016/j.tibtech.2018.01.003. 
      Epub 2018 Feb 6.