PMID- 29422822
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1642-395X (Print)
IS  - 2299-0046 (Electronic)
IS  - 1642-395X (Linking)
VI  - 34
IP  - 6
DP  - 2017 Dec
TI  - Thyroid function and thyroid autoantibodies in patients with chronic spontaneous 
      urticaria.
PG  - 566-572
LID - 10.5114/ada.2017.72464 [doi]
AB  - INTRODUCTION: Chronic urticaria (CU) is a skin disease caused by autoantibodies 
      against high affinity immunoglobulin E (IgE) receptor and against IgE. It is 
      characterized by hives, erythematous wheals and redness present minimum twice a 
      week for at least 6 weeks. It is observed that there is a strong association 
      between CU and autoimmune diseases, such as autoimmune thyroiditis (AT). AIM: To 
      verify the frequency of AT in patients suffering from chronic spontaneous 
      urticaria (CSU) and to confirm the coexistence of CU and AT in the Polish 
      population. MATERIAL AND METHODS: One hundred and forty-eight patients with CSU 
      were included to the study. The presence of anti-thyroperoxydase antibodies 
      (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) was checked and 
      thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) 
      concentration was measured. Results were compared with outcomes in a group of 35 
      patients with no history of skin disease. RESULTS: Thirty-three patients were 
      diagnosed with AT. Frequency of elevated anti-TPO (p = 0.0045) and anti-Tg (p = 
      0.013) levels was much higher in patients with CU. A comparison of the current 
      study and previous ones was conducted. In a group with CU, there was a higher 
      risk of elevated anti-TPO (OR = 6.69) and anti-Tg (OR = 6.01) levels. 
      CONCLUSIONS: There is a statistically significant difference in the presence of 
      AT between the patients with CU and the whole population. Doctors should consider 
      examining patients with CU for AT. Adequate therapy and guidance for patients 
      could be implemented at an early stage of thyroid disease and help induce 
      remission of skin disorders.
FAU - Czarnecka-Operacz, Magdalena
AU  - Czarnecka-Operacz M
AD  - Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Sadowska-Przytocka, Anna
AU  - Sadowska-Przytocka A
AD  - Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Jenerowicz, Dorota
AU  - Jenerowicz D
AD  - Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Szeliga, Anna
AU  - Szeliga A
AD  - Student's Scientific Society, Poznan University of Medical Sciences, Poznan, 
      Poland.
FAU - Adamski, Zygmunt
AU  - Adamski Z
AD  - Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
FAU - Lacka, Katarzyna
AU  - Lacka K
AD  - Department of Endocrinology, Metabolism and Internal Medicine, Poznan University 
      of Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
DEP - 20171231
PL  - Poland
TA  - Postepy Dermatol Alergol
JT  - Postepy dermatologii i alergologii
JID - 101168357
PMC - PMC5799761
OTO - NOTNLM
OT  - anti-thyroglobulin antibodies
OT  - anti-thyroperoxydase antibodies
OT  - autoimmune thyroiditis
OT  - autoimmunity
OT  - chronic urticaria
OT  - thyroid
EDAT- 2018/02/10 06:00
MHDA- 2018/02/10 06:01
PMCR- 2017/12/01
CRDT- 2018/02/10 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2016/10/17 00:00 [accepted]
PHST- 2018/02/10 06:00 [entrez]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/02/10 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 31386 [pii]
AID - 10.5114/ada.2017.72464 [doi]
PST - ppublish
SO  - Postepy Dermatol Alergol. 2017 Dec;34(6):566-572. doi: 10.5114/ada.2017.72464. 
      Epub 2017 Dec 31.