PMID- 29422901
OWN - NLM
STAT- MEDLINE
DCOM- 20190228
LR  - 20190228
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Identification of a Potential Common Ancestor for Mammalian Cross-Presenting 
      Dendritic Cells in Teleost Respiratory Surfaces.
PG  - 59
LID - 10.3389/fimmu.2018.00059 [doi]
LID - 59
AB  - Dendritic cells (DCs) are highly specialized antigen-presenting cells that bridge 
      innate and adaptive immune responses in vertebrates, being key modulators in the 
      initiation of specific responses. Although teleost fish present the main elements 
      of a fully developed adaptive immune system, not many studies have focused on 
      identifying specific DC subsets in teleost species. Previous work from our group 
      identified in rainbow trout (Oncorhynchus mykiss) skin a DC subpopulation 
      co-expressing CD8alpha and major histocompatibility complex II beta on the cell surface. 
      Interestingly, these CD8(+) DCs expressed common unique markers of mammalian 
      cross-presenting DCs, a DC subset with an important role in antigen presentation 
      and activation of CD8(+) T cytotoxic lymphocytes. In this study, we have 
      identified a similar DC subset in rainbow trout gills that also transcribes 
      molecules uniquely expressed on diverse mammalian cross-presenting DC populations 
      such as CD8, CD103, CD141, Batf3, IFN regulatory protein 8, and toll-like 
      receptor 3. Hence, we have undertaken a broad phenotypic and functional 
      characterization of this new DC subset that includes the confirmation of novel 
      capacities for DCs in teleost, such an IgM-binding capacity and responsiveness to 
      CD40 ligand. Furthermore, our results show that in gills, this DC subset shows 
      some different phenotypic and functional characteristics when compared with their 
      homologs in the skin, suggesting an adaptation of the cells to different mucosal 
      tissues or different maturation status depending on their location. Our findings 
      contribute to increase our knowledge on fish cross-presenting DCs, an important 
      cell population to take into account for the future design of mucosal vaccination 
      strategies.
FAU - Soleto, Irene
AU  - Soleto I
AD  - Centro de Investigacion en Sanidad Animal (CISA), INIA, Valdeolmos, Spain.
FAU - Fischer, Uwe
AU  - Fischer U
AD  - Bundesforschungsinstitut fur Tiergesundheit, Friedrich-Loeffler-Institut (FLI), 
      Insel Riems, Germany.
FAU - Tafalla, Carolina
AU  - Tafalla C
AD  - Centro de Investigacion en Sanidad Animal (CISA), INIA, Valdeolmos, Spain.
FAU - Granja, Aitor G
AU  - Granja AG
AD  - Centro de Investigacion en Sanidad Animal (CISA), INIA, Valdeolmos, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180125
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin M)
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Biomarkers
MH  - CD40 Ligand
MH  - Cell Proliferation
MH  - Cross-Priming/*immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Female
MH  - Fishes/*immunology
MH  - Gills/*immunology/metabolism
MH  - Immunoglobulin M/immunology
MH  - Immunophenotyping
MH  - Leukocytes/immunology/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Phagocytes/immunology/metabolism
MH  - Phagocytosis/immunology
MH  - T-Lymphocytes/immunology/metabolism
PMC - PMC5788898
OTO - NOTNLM
OT  - CD8
OT  - cross-presentation
OT  - dendritic cells
OT  - gills
OT  - major histocompatibility complex II
OT  - rainbow trout
OT  - respiratory surfaces
EDAT- 2018/02/10 06:00
MHDA- 2018/02/10 06:01
PMCR- 2018/01/01
CRDT- 2018/02/10 06:00
PHST- 2017/09/21 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2018/02/10 06:00 [entrez]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/02/10 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00059 [doi]
PST - epublish
SO  - Front Immunol. 2018 Jan 25;9:59. doi: 10.3389/fimmu.2018.00059. eCollection 2018.