PMID- 29423073 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220331 IS - 1949-2553 (Electronic) IS - 1949-2553 (Linking) VI - 9 IP - 3 DP - 2018 Jan 9 TI - Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 diabetes patients and healthy controls. PG - 3653-3662 LID - 10.18632/oncotarget.23342 [doi] AB - BACKGROUND AND AIMS: Type 2 diabetes (T2DM) is associated with cognitive deficits. However, their pathophysiological mechanisms are still unknown. Recent study suggests that brain-derived neurotrophic factor (BDNF) is correlated with cognitive deficits in T2DM patients. This study was to determine whether altered serum BDNF levels and cognitive deficits depended on the BDNF Val66Met polymorphism in T2DM. RESULTS: The BDNF Val66Met polymorphism may not contribute directly to the susceptibility to T2DM. The total and nearly all index scores (all p < 0.01) except for the attention and visuospatial/constructional indexes (both p > 0.05) of RBANS were markedly decreased in T2DM compared with healthy controls. Serum BDNF levels were significantly lower in patients than that in controls (p < 0.001), and BDNF was positively associated with delayed memory in patients (p < 0.05). The Met variant was associated with worse delayed memory performance among T2DM patients but not among normal controls. Moreover, serum BDNF was positively associated with delayed memory among Met homozygote patients (beta = 0.29, t = 2.21, p = 0.033), while serum BDNF was negatively associated the RBANS total score (beta = -0.92, t = -3.40, p = 0.002) and language index (beta = -1.17, t = -3.54, p = 0.001) among Val homozygote T2DM patients. CONCLUSIONS: BDNF gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. The association between lower BDNF serum levels and cognitive impairment in T2DM is dependent on the BDNF Val66Met polymorphism. METHODS: We recruited 311 T2DM patients and 346 healthy controls and compared them on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), serum BDNF levels, and the BDNF Val66Met polymorphism. FAU - Zhen, Yan-Feng AU - Zhen YF AD - Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, China. FAU - Liu, Xing-Yu AU - Liu XY AD - Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan, China. FAU - Zhou, Dong-Hao AU - Zhou DH AD - Department of Endocrinology, Linyi People's Hospital, Linyi, China. FAU - Du, Xiangdong AU - Du X AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China. FAU - Yin, Guangzhong AU - Yin G AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China. FAU - Zhang, Yingyang AU - Zhang Y AD - Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, China. FAU - Fang, Hui AU - Fang H AD - Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, China. FAU - Xu, Gang AU - Xu G AD - Department of Burn, Tangshan Gongren Hospital, Tangshan, China. FAU - Soares, Jair C AU - Soares JC AD - Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Zhang, Xiang Yang AU - Zhang XY AD - Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. LA - eng PT - Journal Article DEP - 20171216 PL - United States TA - Oncotarget JT - Oncotarget JID - 101532965 PMC - PMC5790490 OTO - NOTNLM OT - association OT - brain-derived neurotrophic factor OT - cognition OT - polymorphism OT - type 2 diabetes COIS- CONFLICTS OF INTEREST None. EDAT- 2018/02/10 06:00 MHDA- 2018/02/10 06:01 PMCR- 2018/01/09 CRDT- 2018/02/10 06:00 PHST- 2017/08/05 00:00 [received] PHST- 2017/11/23 00:00 [accepted] PHST- 2018/02/10 06:00 [entrez] PHST- 2018/02/10 06:00 [pubmed] PHST- 2018/02/10 06:01 [medline] PHST- 2018/01/09 00:00 [pmc-release] AID - 23342 [pii] AID - 10.18632/oncotarget.23342 [doi] PST - epublish SO - Oncotarget. 2017 Dec 16;9(3):3653-3662. doi: 10.18632/oncotarget.23342. eCollection 2018 Jan 9.