PMID- 29424687
OWN - NLM
STAT- MEDLINE
DCOM- 20190730
LR  - 20211006
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 7
DP  - 2018 Feb 9
TI  - Architecture of the human mTORC2 core complex.
LID - 10.7554/eLife.33101 [doi]
LID - e33101
AB  - The mammalian target of rapamycin (mTOR) is a key protein kinase controlling 
      cellular metabolism and growth. It is part of the two structurally and 
      functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of 
      mTOR occurs in diabetes, cancer and neurological disease. We report the 
      architecture of human mTORC2 at intermediate resolution, revealing a conserved 
      binding site for accessory proteins on mTOR and explaining the structural basis 
      for the rapamycin insensitivity of the complex.
CI  - (c) 2018, Stuttfeld et al.
FAU - Stuttfeld, Edward
AU  - Stuttfeld E
AUID- ORCID: 0000-0003-3932-9076
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Aylett, Christopher Hs
AU  - Aylett CH
AUID- ORCID: 0000-0003-0662-6664
AD  - Institute for Molecular Biology and Biophysics, Zurich, Switzerland.
FAU - Imseng, Stefan
AU  - Imseng S
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Boehringer, Daniel
AU  - Boehringer D
AD  - Institute for Molecular Biology and Biophysics, Zurich, Switzerland.
FAU - Scaiola, Alain
AU  - Scaiola A
AUID- ORCID: 0000-0003-3233-3910
AD  - Institute for Molecular Biology and Biophysics, Zurich, Switzerland.
FAU - Sauer, Evelyn
AU  - Sauer E
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Hall, Michael N
AU  - Hall MN
AD  - Biozentrum, University of Basel, Basel, Switzerland.
FAU - Maier, Timm
AU  - Maier T
AUID- ORCID: 0000-0002-7459-1363
AD  - Biozentrum, University of Basel, Basel, Switzerland.
AD  - Institute for Molecular Biology and Biophysics, Zurich, Switzerland.
FAU - Ban, Nenad
AU  - Ban N
AUID- ORCID: 0000-0002-9527-210X
AD  - Institute for Molecular Biology and Biophysics, Zurich, Switzerland.
LA  - eng
GR  - 609883/ERC_/European Research Council/International
GR  - 206212/Z/17/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180209
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
MH  - *Cryoelectron Microscopy
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 2/*chemistry/*metabolism
MH  - Models, Molecular
MH  - Protein Binding
MH  - Protein Conformation
PMC - PMC5837792
OTO - NOTNLM
OT  - cell growth
OT  - electron microscopy
OT  - human
OT  - molecular biophysics
OT  - regulation
OT  - structural biology
COIS- ES, CA, SI, DB, AS, ES, MH, TM, NB No competing interests declared
EDAT- 2018/02/10 06:00
MHDA- 2019/07/31 06:00
PMCR- 2018/02/09
CRDT- 2018/02/10 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/02/08 00:00 [accepted]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2019/07/31 06:00 [medline]
PHST- 2018/02/10 06:00 [entrez]
PHST- 2018/02/09 00:00 [pmc-release]
AID - 33101 [pii]
AID - 10.7554/eLife.33101 [doi]
PST - epublish
SO  - Elife. 2018 Feb 9;7:e33101. doi: 10.7554/eLife.33101.