PMID- 29425256
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20181004
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 50
IP  - 3
DP  - 2018 Mar 1
TI  - Dihydromyricetin improves type 2 diabetes-induced cognitive impairment via 
      suppressing oxidative stress and enhancing brain-derived neurotrophic 
      factor-mediated neuroprotection in mice.
PG  - 298-306
LID - 10.1093/abbs/gmy003 [doi]
AB  - Type 2 diabetes mellitus (T2DM) leads to cognitive impairment (CI), but there 
      have been no effective pharmacotherapies or drugs for cognitive dysfunction in 
      T2DM. Dihydromyricetin (DHM) is a natural flavonoid compound extracted from the 
      leaves of Ampelopsis grossedentata and has various pharmacological effects 
      including anti-oxidant and anti-diabetes. Thus, we investigated the effects of 
      DHM on CI in T2DM mouse model and its possible mechanism. To induce T2DM, mice 
      were fed with high-sugar and high-fat diet for 8 weeks, followed by a low dose 
      streptozotocin (STZ) administration. After the successful induction of T2DM mouse 
      model, mice were treated respectively with equal volume of saline (T2DM group), 
      125 mg/kg/d DHM (L-DHM group), or 250 mg/kg/d DHM (H-DHM group). After 16 weeks 
      of DHM administration, the body weight (BW), fasting blood glucose, blood lipids, 
      intraperitoneal glucose tolerance (IPGT), and cognitive function were determined. 
      Then, alterations in the expressions of oxidative stress markers and 
      brain-derived neurotrophic factor (BDNF) in the hippocampus were investigated. 
      Our findings demonstrated that DHM could significantly ameliorate CI and reverse 
      aberrant glucose and lipid metabolism in T2DM mice, likely through the 
      suppression of oxidative stress and enhancement of BDNF-mediated neuroprotection. 
      In conclusion, our results suggest that DHM is a promising candidate for the 
      treatment of T2DM-induced cognitive dysfunction.
FAU - Ling, Hongyan
AU  - Ling H
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
FAU - Zhu, Zemei
AU  - Zhu Z
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
AD  - Department of Medicine, Changde Vocational Technical College, Changde 415000, 
      China.
FAU - Yang, Jihua
AU  - Yang J
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
FAU - He, Jianqin
AU  - He J
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
FAU - Yang, Sisi
AU  - Yang S
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
FAU - Wu, Di
AU  - Wu D
AD  - Department of Physiology, School of Medicine, University of South China, Hengyang 
      421001, China.
FAU - Feng, Shuidong
AU  - Feng S
AD  - Department of Social Medicine and Health Service Management, School of Public 
      Health, University of South China, Hengyang 421001, China.
FAU - Liao, Duanfang
AU  - Liao D
AD  - Division of Stem Cell Regulation and Application, Key Laboratory for Quality 
      Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, 
      Changsha 410000, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonols)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - KD8QND6427 (dihydromyricetin)
SB  - IM
MH  - Ampelopsis/chemistry
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cognitive Dysfunction/etiology/metabolism/*prevention & control
MH  - Diabetes Mellitus, Experimental/blood/complications
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Flavonols/*pharmacology
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Neuroprotection/*drug effects
MH  - Neuroprotective Agents/pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology
EDAT- 2018/02/10 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/02/10 06:00
PHST- 2017/10/01 00:00 [received]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/02/10 06:00 [entrez]
AID - 4841912 [pii]
AID - 10.1093/abbs/gmy003 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2018 Mar 1;50(3):298-306. doi: 
      10.1093/abbs/gmy003.