PMID- 29425916
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20201209
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 343
DP  - 2018 May 2
TI  - Genetically defined fear-induced aggression: Focus on BDNF and its receptors.
PG  - 102-110
LID - S0166-4328(17)31509-7 [pii]
LID - 10.1016/j.bbr.2018.01.034 [doi]
AB  - Brain-derived neurotrophic factor (BDNF), its precursor proBDNF, BDNF 
      pro-peptide, BDNF mRNA levels, as well as TrkB and p75(NTR) receptors mRNA and 
      protein levels, were studied in the brain of rats, selectively bred for more than 
      85 generations for either the high level or the lack of fear-induced aggressive 
      behavior. Furthermore, we have found that rats of aggressive strain demonstrated 
      both high level of aggression toward humans and increased amplitude of acoustic 
      startle response compared to rats selectively bred for the lack of fear-induced 
      aggression. Significant increase in the BDNF mRNA, mature BDNF and proBDNF 
      protein levels in the raphe nuclei (RN), hippocampus (Hc), nucleus accumbens 
      (NAcc), amygdala, striatum and hypothalamus (Ht) of aggressive rats was revealed. 
      The BDNF/proBDNF ratio was significantly reduced in the Hc and NAcc of highly 
      aggressive rats suggesting prevalence of the proBDNF in these structures. In the 
      Hc and frontal cortex (FC) of aggressive rats, the level of the full-length TrkB 
      (TrkB-FL) receptor form was decreased, whereas the truncated TrkB (TrkB-T) 
      protein level was increased in the RN, FC, substantia nigra and Ht. The 
      TrkB-FL/TrkB-T ratio was significantly decreased in highly aggressive rats 
      suggesting TrkB-T is predominant in highly aggressive rats. The p75(NTR) 
      expression was slightly changed in majority of studied brain structures of 
      aggressive rats. The data indicate the BDNF system in the brain of aggressive and 
      nonaggressive animals is extremely different at all levels, from transcription to 
      reception, suggesting significant role of BDNF system in the development of 
      highly aggressive phenotype.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Ilchibaeva, Tatiana V
AU  - Ilchibaeva TV
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia. Electronic address: rbicehok@mail.ru.
FAU - Tsybko, Anton S
AU  - Tsybko AS
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia.
FAU - Kozhemyakina, Rimma V
AU  - Kozhemyakina RV
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia.
FAU - Kondaurova, Elena M
AU  - Kondaurova EM
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia.
FAU - Popova, Nina K
AU  - Popova NK
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia.
FAU - Naumenko, Vladimir S
AU  - Naumenko VS
AD  - The Federal Research Center Institute of Cytology and Genetics, The Siberian 
      Branch of Russian Academy of Sciences, Lavrentyeva av.10, Novosibirsk, 630090, 
      Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180206
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Diterpenes)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 131400-39-0 (brianolide)
RN  - 136958-07-1 (Ngfr protein, rat)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Aggression/*physiology
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Diterpenes/*metabolism
MH  - Fear/*physiology
MH  - Genetic Predisposition to Disease
MH  - Male
MH  - Nerve Tissue Proteins
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Growth Factor
MH  - Receptors, Nerve Growth Factor/*metabolism
MH  - Reflex, Startle/physiology
MH  - Species Specificity
OTO - NOTNLM
OT  - BDNF
OT  - BDNF pro-peptide
OT  - Expression
OT  - Fear-induced aggression
OT  - Full-length TrkB receptor
OT  - Truncated TrkB receptor
OT  - p75(NTR) Receptor
OT  - proBDNF
EDAT- 2018/02/10 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/02/10 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2018/01/30 00:00 [revised]
PHST- 2018/01/31 00:00 [accepted]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/02/10 06:00 [entrez]
AID - S0166-4328(17)31509-7 [pii]
AID - 10.1016/j.bbr.2018.01.034 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 May 2;343:102-110. doi: 10.1016/j.bbr.2018.01.034. Epub 
      2018 Feb 6.