PMID- 29425917
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20200325
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 343
DP  - 2018 May 2
TI  - Incorporation of new neurons in the olfactory bulb after paced mating in the 
      female rat.
PG  - 95-101
LID - S0166-4328(17)31883-1 [pii]
LID - 10.1016/j.bbr.2018.02.006 [doi]
AB  - One of the regions that constantly produces neurogenesis in the adult brain is 
      the subventricular zone (SVZ), whose new cells migrate to the olfactory bulbs 
      (OB). When the females regulate the copulatory events (paced mating) the number 
      of new cells in the SVZ increases, as well as those observed in the OB 15 days 
      later. However, no changes were observed in the number of cells 45 days after the 
      females paced the sexual interaction. Constant sensory stimulation is an 
      important promoter of cell survival in the OB circuit. Hence, we increased the 
      number of mating sessions in this study to cover the period where stimulation of 
      the new cells is critical for their incorporation into pre-existing circuits in 
      the OB. Ovariectomized female Wistar rats, were injected with the mitotic marker 
      5-bromo-2'-deoxyuridine (BrdU, 100 mg/kg, per injection) before, at the end and 
      one hour after mating. Sexual behavior was recorded for 1 h in 10 weekly 
      sessions. After the last mating session, brain sections were processed to 
      determine BrdU immunoreactivity. Our results indicate that females that paced the 
      sexual interaction for 10 sessions had a higher number of cells in the glomerular 
      layer (GL) of the accessory olfactory bulb (AOB) and a higher number of neurons 
      in the granular layer (GrL) of the main olfactory bulb (MOB) in comparison to the 
      control group. These results indicate that continued sexual interaction 
      contributes to the integration of new cells and neurons, induced in the first 
      sexual experience, into pre-exiting circuits of the OB.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Alvarado-Martinez, R
AU  - Alvarado-Martinez R
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus 
      UNAM-Juriquilla, Blvd Juriquilla 3001, 76230.
FAU - Paredes, R G
AU  - Paredes RG
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus 
      UNAM-Juriquilla, Blvd Juriquilla 3001, 76230. Electronic address: 
      rparedes@unam.mx.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180206
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Rbfox3 protein, rat)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Antigens, Nuclear/metabolism
MH  - Bromodeoxyuridine
MH  - Cell Count
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurogenesis/*physiology
MH  - Neurons/*cytology/*physiology
MH  - Olfactory Bulb/*cytology/*physiology
MH  - Ovariectomy
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/*physiology
OTO - NOTNLM
OT  - Accessory olfactory bulb (AOB)
OT  - Main olfactory bulb (MOB)
OT  - Neurogenesis
OT  - Non-paced mating (NPM)
OT  - Paced mating (PM)
EDAT- 2018/02/10 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/02/10 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/02/03 00:00 [revised]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/02/10 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/02/10 06:00 [entrez]
AID - S0166-4328(17)31883-1 [pii]
AID - 10.1016/j.bbr.2018.02.006 [doi]
PST - ppublish
SO  - Behav Brain Res. 2018 May 2;343:95-101. doi: 10.1016/j.bbr.2018.02.006. Epub 2018 
      Feb 6.