PMID- 29425973 OWN - NLM STAT- MEDLINE DCOM- 20190131 LR - 20191210 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 188 DP - 2018 May 1 TI - Metabolic and cognitive improvement from switching to saccharin or water following chronic consumption by female rats of 10% sucrose solution. PG - 162-172 LID - S0031-9384(18)30052-0 [pii] LID - 10.1016/j.physbeh.2018.02.008 [doi] AB - High consumption of sugar-sweetened beverages (SSBs) is a risk factor for weight gain and metabolic disease. Whether this risk is reduced by switching to 'diet' beverages containing low-calorie sweeteners (LCS) is controversial. Two experiments modeled whether a switch from SSB to LCS beverages produced positive outcomes on behavioral and metabolic measures. Both experiments consisted of a Stage 1, in which adult female rats received unrestricted access to 10% sucrose solution in addition to chow and water for 4 (Experiment 1) or 8 weeks (Experiment 2). In Stage 2 rats were switched to either saccharin (Suc-Sacch) or water (Suc-Water) or remained on 10% sucrose (Suc-Suc) for a further 4 (Experiment 1) or 7 weeks (Experiment 2). Experiment 2 contained a fourth group that was maintained on water throughout (Water-Water). In both experiments energy intake and weight gain in Stage 2 was reduced for Suc-Sacch and Suc-Water groups relative to the Suc-Suc groups and at cull the Suc-Suc groups showed poorer insulin sensitivity and greater g/kg fat than Suc-Water and Suc-Sacch groups. In Experiment 2 short-term place recognition memory was impaired at the end of Stage 1 but recovered to a similar extent in the Suc-Water and Suc-Sacch groups; when the latter groups were compared with the Water-Water group, recovery was found to be essentially complete. A higher saccharin concentration in Experiment 2 than in Experiment 1 increased absolute amounts of saccharin ingested but intake solution volumes remained low. These results show that switching from sucrose to either water or saccharin produces equivalent improvements on both metabolic and cognitive measures. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Kendig, Michael D AU - Kendig MD AD - School of Psychology, University of Sydney, Australia. FAU - Fu, Michelle X AU - Fu MX AD - School of Psychology, University of Sydney, Australia. FAU - Rehn, Simone AU - Rehn S AD - School of Psychology, University of Sydney, Australia. FAU - Martire, Sarah I AU - Martire SI AD - School of Psychology, University of Sydney, Australia. FAU - Boakes, Robert A AU - Boakes RA AD - School of Psychology, University of Sydney, Australia. Electronic address: bob.boakes@sydney.edu.au. FAU - Rooney, Kieron B AU - Rooney KB AD - Faculty of Health Sciences and Charles Perkins Centre, University of Sydney, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180206 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 0 (Triglycerides) RN - 059QF0KO0R (Water) RN - FST467XS7D (Saccharin) SB - IM MH - Adipose Tissue/*metabolism MH - Analysis of Variance MH - Animals MH - Body Weight/physiology MH - Eating/physiology MH - Fasting/physiology MH - Female MH - Hyperphagia/*etiology/prevention & control MH - Insulin Resistance/*physiology MH - Rats MH - Rats, Sprague-Dawley MH - Recognition, Psychology/*physiology MH - Saccharin/*adverse effects MH - Triglycerides/blood MH - Water/*adverse effects OTO - NOTNLM OT - Fat mass OT - Insulin resistance OT - Low-calorie sweetener OT - Place memory OT - Rat OT - Sugar OT - Weight gain EDAT- 2018/02/10 06:00 MHDA- 2019/02/01 06:00 CRDT- 2018/02/10 06:00 PHST- 2017/12/19 00:00 [received] PHST- 2018/02/01 00:00 [revised] PHST- 2018/02/03 00:00 [accepted] PHST- 2018/02/10 06:00 [pubmed] PHST- 2019/02/01 06:00 [medline] PHST- 2018/02/10 06:00 [entrez] AID - S0031-9384(18)30052-0 [pii] AID - 10.1016/j.physbeh.2018.02.008 [doi] PST - ppublish SO - Physiol Behav. 2018 May 1;188:162-172. doi: 10.1016/j.physbeh.2018.02.008. Epub 2018 Feb 6.