PMID- 29426666
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20211204
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 28
IP  - 2
DP  - 2018 Feb
TI  - The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus.
PG  - 307-316
LID - S0924-977X(17)32030-8 [pii]
LID - 10.1016/j.euroneuro.2017.12.004 [doi]
AB  - Accumulating evidence suggests that certain gut microbiota have 
      antidepressant-like behavioural effects and that the microbiota can regulate 
      neurogenesis and the expression of brain-derived neurotrophic factor (BDNF) in 
      the hippocampus. The precise mechanisms underlying these effects are not yet 
      clear. However, the vagus nerve is one of the primary bidirectional routes of 
      communication between the gut and the brain and thus may represent a candidate 
      mechanism. Yet, relatively little is known about the direct influence of vagus 
      nerve activity on hippocampal function and plasticity. Thus, the aim of the 
      present study was to determine whether constitutive vagus nerve activity 
      contributes to the regulation of neurogenesis and BDNF mRNA expression in the 
      hippocampus. To this end, we examined the impact of subdiaphragmatic vagotomy in 
      adult mice on these parameters. We found that vagotomy decreased BDNF mRNA in all 
      areas of the hippocampus. Vagotomy also reduced the proliferation and survival of 
      newly born cells and decreased the number of immature neurons, particularly those 
      with a more complex dendritic morphology. Taken together, these findings suggest 
      that vagal nerve activity influences neurogenesis and BDNF mRNA expression in the 
      adult hippocampus.
CI  - Copyright (c) 2017 Elsevier B.V. and ECNP. All rights reserved.
FAU - O'Leary, Olivia F
AU  - O'Leary OF
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; 
      APC Microbiome Institute, University College Cork, Cork, Ireland. Electronic 
      address: o.oleary@ucc.ie.
FAU - Ogbonnaya, Ebere S
AU  - Ogbonnaya ES
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
FAU - Felice, Daniela
AU  - Felice D
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; 
      APC Microbiome Institute, University College Cork, Cork, Ireland.
FAU - Levone, Brunno R
AU  - Levone BR
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
FAU - C Conroy, Lorraine
AU  - C Conroy L
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
FAU - Fitzgerald, Patrick
AU  - Fitzgerald P
AD  - APC Microbiome Institute, University College Cork, Cork, Ireland.
FAU - Bravo, Javier A
AU  - Bravo JA
AD  - APC Microbiome Institute, University College Cork, Cork, Ireland.
FAU - Forsythe, Paul
AU  - Forsythe P
AD  - The McMaster Brain-Body Institute, McMaster University, Hamilton, Ontario, Canada 
      L8N 4A6; Firestone Institute for Respiratory Health and Department of Medicine, 
      McMaster University, Hamilton, Ontario, Canada L8N 4A6.
FAU - Bienenstock, John
AU  - Bienenstock J
AD  - The McMaster Brain-Body Institute, McMaster University, Hamilton, Ontario, Canada 
      L8N 4A6; Department of Pathology and Molecular Medicine, McMaster University, 
      Hamilton, Ontario, Canada L8N 4A6.
FAU - Dinan, Timothy G
AU  - Dinan TG
AD  - APC Microbiome Institute, University College Cork, Cork, Ireland; Department of 
      Psychiatry & Neurobehavioural Science, University College Cork, Cork, Ireland.
FAU - Cryan, John F
AU  - Cryan JF
AD  - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; 
      APC Microbiome Institute, University College Cork, Cork, Ireland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Messenger)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Survival/physiology
MH  - Doublecortin Domain Proteins
MH  - Eating/physiology
MH  - Gene Expression Regulation/physiology
MH  - Hippocampus/cytology/*physiology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurogenesis/*physiology
MH  - Neurons/cytology/physiology
MH  - Neuropeptides/metabolism
MH  - RNA, Messenger/metabolism
MH  - Sincalide/administration & dosage/metabolism
MH  - Vagus Nerve/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - Dorsal hippocampus
OT  - Microbiota
OT  - Neurogenesis
OT  - Vagus nerve
OT  - Ventral hippocampus
EDAT- 2018/02/11 06:00
MHDA- 2019/01/15 06:00
CRDT- 2018/02/11 06:00
PHST- 2017/05/02 00:00 [received]
PHST- 2017/10/26 00:00 [revised]
PHST- 2017/12/02 00:00 [accepted]
PHST- 2018/02/11 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/02/11 06:00 [entrez]
AID - S0924-977X(17)32030-8 [pii]
AID - 10.1016/j.euroneuro.2017.12.004 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2018 Feb;28(2):307-316. doi: 
      10.1016/j.euroneuro.2017.12.004.