PMID- 29427742
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190325
IS  - 1879-0542 (Electronic)
IS  - 0165-2478 (Linking)
VI  - 196
DP  - 2018 Apr
TI  - Modulation of dendritic cell by pathogen antigens: Where do we stand?
PG  - 91-102
LID - S0165-2478(17)30528-X [pii]
LID - 10.1016/j.imlet.2018.02.001 [doi]
AB  - Dendritic cells (DCs) are essential players in the activation of T cells and in 
      the development of adaptive immune response towards invading pathogens. Upon 
      antigen (Ag) recognition of Pathogen Associated Molecular Patterns (PAMPs) by 
      their receptors (PRRs), DCs are activated and acquire an inflammatory profile. 
      DCs have the ability to direct the profile of helper T (Th) cells towards Th1, 
      Th2, Th17, Th9 and regulatory (Treg) cells. Each subset of Th cells presents a 
      unique gene expression signature and is endowed with the ability to conduct or 
      suppress effector cells in inflammation. Pathogens target DCs during infection. 
      Many studies demonstrated that antigens and molecules derived from pathogens have 
      the ability to dampen DC maturation and activation, leading these cells to a 
      permissive state or tolerogenic profile (tolDCs). Although tolDCs may represent a 
      hindrance in infection control, they could be positively used to modulate 
      inflammatory disorders, such as autoimmune diseases. In this review, we focus on 
      discussing findings that use pathogen-antigen modulated DCs and tolDCs in 
      prophylactics and therapeutics approaches for vaccination against infectious 
      diseases or inflammatory disorders.
CI  - Copyright (c) 2018 European Federation of Immunological Societies. All rights 
      reserved.
FAU - Peron, Gabriela
AU  - Peron G
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil. Electronic address: 
      g163945@dac.unicamp.br.
FAU - de Lima Thomaz, Livia
AU  - de Lima Thomaz L
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
FAU - Camargo da Rosa, Larissa
AU  - Camargo da Rosa L
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
FAU - Thome, Rodolfo
AU  - Thome R
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, USA.
FAU - Cardoso Verinaud, Liana Maria
AU  - Cardoso Verinaud LM
AD  - Department of Structural and Functional Biology, Institute of Biology, University 
      of Campinas, UNICAMP, Campinas, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180207
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Antigens)
SB  - IM
MH  - Adaptive Immunity/*immunology
MH  - Animals
MH  - Antigens/*immunology
MH  - Cell Differentiation/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Inflammation/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
MH  - T-Lymphocytes, Regulatory/cytology/*immunology
OTO - NOTNLM
OT  - Dendritic cell-based vaccination
OT  - Dendritic cells
OT  - Inflammatory disorders
OT  - Pathogen antigens
OT  - Tolerogenic dendritic cells
EDAT- 2018/02/11 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/02/11 06:00
PHST- 2017/11/07 00:00 [received]
PHST- 2018/01/29 00:00 [revised]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/02/11 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/02/11 06:00 [entrez]
AID - S0165-2478(17)30528-X [pii]
AID - 10.1016/j.imlet.2018.02.001 [doi]
PST - ppublish
SO  - Immunol Lett. 2018 Apr;196:91-102. doi: 10.1016/j.imlet.2018.02.001. Epub 2018 
      Feb 7.