PMID- 29428305
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 109
IP  - 3
DP  - 2018 Mar
TI  - High-molecular-weight adiponectin is inversely associated with sympathetic 
      activity in polycystic ovary syndrome.
PG  - 532-539
LID - S0015-0282(17)32074-5 [pii]
LID - 10.1016/j.fertnstert.2017.11.020 [doi]
AB  - OBJECTIVE: To examine the role of high-molecular-weight (HMW) adiponectin and its 
      relationship to sympathetic activity in women with polycystic ovary syndrome 
      (PCOS). DESIGN: Cross sectional study using biobanked samples. SETTING: Not 
      applicable. PATIENT(S): Premenopausal women with PCOS (n = 46, Rotterdam 
      diagnostic criteria) and without PCOS (n = 22). INTERVENTION(S): None. MAIN 
      OUTCOME MEASURE(S): High-molecular-weight adiponectin levels with secondary 
      outcomes of sympathetic activity and leptin levels. RESULT(S): The 
      high-molecular-weight adiponectin level was lower in women with PCOS (median 2.2 
      [interquartile range (IQR)2.3] mug/mL) than in controls (median 3 [IQR2.5] mug/mL) 
      (age and BMI adjusted), and it correlated inversely with the values measured for 
      homeostatic model of assessment of insulin resistance (HOMA-IR), fasting insulin, 
      triglycerides, and free androgen index and positively with sex hormone-binding 
      globulin (SHBG) and high-density lipoprotein cholesterol in all participants and 
      in the PCOS group. In the PCOS group, sympathetic activity (burst frequency) was 
      statistically significantly higher than in controls (median 26 [IQR11] vs. median 
      22 [IQR14], respectively) and correlated inversely with HMW adiponectin (r = 
      -0.230). The leptin levels were similar between the women with PCOS and controls 
      and did not statistically significantly correlate with HMW adiponectin or 
      sympathetic activity. On multiple regression analysis, burst frequency and SHBG 
      explained 40% of the HMW adiponectin variability (B = -0.7; 95% CI -1.2 to -0.2; 
      and B = 0.01; 95% CI 0.004-0.01) in PCOS. CONCLUSION(S): Alongside insulin 
      resistance, increased sympathetic activity is associated with and may modulate 
      HMW adiponectin levels in women with PCOS.
CI  - Copyright (c) 2017 American Society for Reproductive Medicine. All rights reserved.
FAU - Shorakae, Soulmaz
AU  - Shorakae S
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, 
      Melbourne, Victoria, Australia.
FAU - Abell, Sally K
AU  - Abell SK
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, 
      Melbourne, Victoria, Australia.
FAU - Hiam, Danielle S
AU  - Hiam DS
AD  - Institute of Sport Exercise and Active Living (ISEAL), Victoria University, 
      Melbourne, Victoria, Australia.
FAU - Lambert, Elisabeth A
AU  - Lambert EA
AD  - Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, 
      Swinburne University of Technology, Melbourne, Victoria, Australia; Department of 
      Physiology, Monash University, Melbourne, Victoria, Australia.
FAU - Eikelis, Nina
AU  - Eikelis N
AD  - Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, 
      Swinburne University of Technology, Melbourne, Victoria, Australia; Human 
      Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, 
      Victoria, Australia.
FAU - Jona, Eveline
AU  - Jona E
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia.
FAU - Sari, Carolina Ika
AU  - Sari CI
AD  - Human Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, 
      Melbourne, Victoria, Australia.
FAU - Stepto, Nigel K
AU  - Stepto NK
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia; Institute of Sport Exercise and Active Living (ISEAL), 
      Victoria University, Melbourne, Victoria, Australia.
FAU - Lambert, Gavin W
AU  - Lambert GW
AD  - Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, 
      Swinburne University of Technology, Melbourne, Victoria, Australia; Human 
      Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, 
      Victoria, Australia.
FAU - de Courten, Barbora
AU  - de Courten B
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, 
      Melbourne, Victoria, Australia.
FAU - Teede, Helena J
AU  - Teede HJ
AD  - Monash Centre for Health Research and Implementation, Monash University, Clayton, 
      Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, 
      Melbourne, Victoria, Australia. Electronic address: helena.teede@monash.edu.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180207
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Lipids)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Leptin/blood
MH  - Linear Models
MH  - Lipids/blood
MH  - Logistic Models
MH  - Molecular Weight
MH  - Multivariate Analysis
MH  - Polycystic Ovary Syndrome/*blood/diagnosis/*physiopathology
MH  - Premenopause/blood
MH  - Randomized Controlled Trials as Topic
MH  - Sex Hormone-Binding Globulin/analysis
MH  - Sympathetic Nervous System/*physiopathology
MH  - Testosterone/blood
MH  - Young Adult
OTO - NOTNLM
OT  - HMW adiponectin
OT  - insulin resistance
OT  - leptin
OT  - polycystic ovary syndrome
OT  - sympathetic nervous system
EDAT- 2018/02/13 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/02/12 06:00
PHST- 2017/07/27 00:00 [received]
PHST- 2017/11/15 00:00 [revised]
PHST- 2017/11/15 00:00 [accepted]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/02/12 06:00 [entrez]
AID - S0015-0282(17)32074-5 [pii]
AID - 10.1016/j.fertnstert.2017.11.020 [doi]
PST - ppublish
SO  - Fertil Steril. 2018 Mar;109(3):532-539. doi: 10.1016/j.fertnstert.2017.11.020. 
      Epub 2018 Feb 7.