PMID- 29429160
OWN - NLM
STAT- MEDLINE
DCOM- 20180306
LR  - 20181202
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 2
DP  - 2018 Feb 8
TI  - [Clinicopathologic features of atypical spindle cell lipomatous tumor].
PG  - 99-104
LID - 10.3760/cma.j.issn.0529-5807.2018.02.004 [doi]
AB  - Objective: To investigate the clinicopathologic characteristics, immunophenotype, 
      differential and diagnostic features of atypical spindle cell lipomatous tumor 
      (ASLT). Methods: Three cases of ASLT were collected from January 2010 to March 
      2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, 
      histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in 
      situ hybridization (FISH) was used to detect MDM2 gene amplification, and 
      relevant literature was reviewed. Results: All three patients were adult males, 
      aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous 
      soft tissue in the head and neck, one was located in the left primary bronchus 
      and one in the latissimus dorsi muscle. Grossly, all three tumors were 
      circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed 
      a focally infiltrative front. These tumors were composed of variable proportions 
      of spindle-shaped and adipocytic cells in a background of variable fibrous and 
      edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed 
      predominately of spindle tumor cells, one of adipocytic cells, and one of equally 
      mixed cell populations. The spindle tumor cells were generally bland-appearing 
      with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was 
      not seen in neither the spindle cells nor the adipocytic cells. By 
      immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells 
      was noted in all cases, definite loss of Rb expression was noted in one of three 
      cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was 
      intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, 
      STAT6, SOX10, CD99, bcl-2, beta-catenin, CD117, GFAP, CK, EMA, SMA and desmin were 
      negative. FISH of MDM2 was done in two cases, and both showed no amplification. 
      The ASLT in the head and neck had two recurrences during 17 months of follow-up, 
      whereas the tumor in the latissimus dorsi was free of disease during 33 months of 
      follow-up. Conclusions: ASLT is a rare subtype of low-grade adipocytic neoplasm 
      and is distinctive from atypical lipomatous tumor/well-differentiated 
      liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a 
      continuous spectrum. ASLT needs to be distinguished from a series of benign and 
      malignant soft tissue tumors.
FAU - Zhao, M
AU  - Zhao M
AD  - Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou 310014, China.
FAU - Wang, Y B
AU  - Wang YB
FAU - Yan, Y J
AU  - Yan YJ
FAU - Wang, W
AU  - Wang W
FAU - Ru, G Q
AU  - Ru GQ
FAU - He, X L
AU  - He XL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (S100 Proteins)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (STAT6 protein, human)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Adult
MH  - Bronchial Neoplasms/chemistry/*pathology
MH  - Head and Neck Neoplasms/chemistry/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoma/chemistry/*pathology
MH  - Liposarcoma/chemistry/pathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Neoplasms/chemistry/*pathology
MH  - Neoplasm Recurrence, Local
MH  - S100 Proteins/analysis
MH  - STAT6 Transcription Factor/analysis
MH  - Superficial Back Muscles
MH  - beta Catenin/analysis
OTO - NOTNLM
OT  - Antigens, CD34
OT  - Diagnosis, differential
OT  - Liposarcoma
OT  - Retinoblastoma protein
EDAT- 2018/02/13 06:00
MHDA- 2018/03/07 06:00
CRDT- 2018/02/13 06:00
PHST- 2018/02/13 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/03/07 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.02.004 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Feb 8;47(2):99-104. doi: 
      10.3760/cma.j.issn.0529-5807.2018.02.004.