PMID- 29429368
OWN - NLM
STAT- MEDLINE
DCOM- 20191004
LR  - 20221207
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 34
IP  - 11
DP  - 2018 Nov
TI  - Effects of statins on all-cause mortality at different low-density-lipoprotein 
      cholesterol levels in Asian patients with type 2 diabetes.
PG  - 1885-1892
LID - 10.1080/03007995.2018.1439829 [doi]
AB  - OBJECTIVE: To investigate the effects of statins on all-cause mortality risk at 
      different low-density lipoprotein cholesterol (LDL-C) levels, and to compare the 
      mortality risk between statin users and non-users with identical LDL-C levels in 
      a type 2 diabetes cohort. METHODS: In total, 10,582 outpatients aged >/=18 years 
      with type 2 diabetes mellitus (T2DM) between 2009 and 2012 were enrolled in this 
      retrospective cohort study in central Taiwan. All-cause mortality events were 
      followed up until the end of 2014. According to the medical records during the 
      follow-up period, the patients were classified into statin (+) and statin (-) 
      groups. Patients were categorized into different LDL-C segments based on their 
      mean LDL-C levels during the 2.8-year follow-up. RESULTS: Non-cardiovascular 
      mortality accounted for more than half the deaths. Overall, statin therapy 
      significantly reduced the all-cause mortality risk in both univariable and 
      multivariable models (hazard ratios = 0.39 and 0.38, respectively). Sub-group 
      analyses showed that the lowest mortality risk occurred in the 80-89 mg/dL 
      segment in the statin (-) group and in the 90-99 mg/dL segment in the statin (+) 
      group. Statin therapy significantly reduced the mortality risk at all LDL-C 
      levels except for low LDL-C (<60 mg/dL). CONCLUSIONS: In addition to reducing 
      LDL-C levels, statin therapy reduced all-cause mortality risk in Taiwanese 
      patients with T2DM. Statins further reduced the mortality risk at most LDL 
      levels. However, at low LDL-C levels, the positive effects of statins may have 
      been nullified.
FAU - Chen, Po-Hsun
AU  - Chen PH
AD  - a Department of Internal Medicine , Taichung Veterans General Hospital, Chiayi 
      branch , Chiayi , Taiwan.
FAU - Wang, Jun-Sing
AU  - Wang JS
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
AD  - c School of Medicine , National Yang Ming University , Taipei , Taiwan.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
AD  - c School of Medicine , National Yang Ming University , Taipei , Taiwan.
AD  - d Center for Geriatrics and Gerontology , Taichung Veterans General Hospital , 
      Taichung , Taiwan.
FAU - Li, Cheng-Hung
AU  - Li CH
AD  - e Cardiovascular Center , Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Wang, Chi-Yen
AU  - Wang CY
AD  - e Cardiovascular Center , Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Hu, Ching-Yun
AU  - Hu CY
AD  - f Department of Internal Medicine , Taichung Veterans General Hospital, Wanqiao 
      branch , Chiayi , Taiwan.
FAU - Fu, Chia-Po-
AU  - Fu CP
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Tsai, Yi-Ting
AU  - Tsai YT
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Lee, Ang-Tse
AU  - Lee AT
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Chen, Yu-Wei
AU  - Chen YW
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Li, Yu-Hsuan
AU  - Li YH
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
FAU - Lee, Chia-Lin
AU  - Lee CL
AD  - b Division of Endocrinology and Metabolism, Department of Internal Medicine , 
      Taichung Veterans General Hospital , Taichung , Taiwan.
AD  - g Department of Public Health, College of Public Health , China Medical 
      University , Taichung , Taiwan.
AD  - h Department of Medical Research , Taichung Veterans General Hospital , Taichung 
      , Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20180312
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/statistics & numerical data
MH  - Cholesterol, LDL/*blood
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/blood/mortality
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - *Hyperlipidemias/blood/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - All-cause mortality
OT  - Low-density lipoprotein cholesterol
OT  - Statin
OT  - Type 2 diabetes mellitus
EDAT- 2018/02/13 06:00
MHDA- 2019/10/08 06:00
CRDT- 2018/02/13 06:00
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2018/02/13 06:00 [entrez]
AID - 10.1080/03007995.2018.1439829 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2018 Nov;34(11):1885-1892. doi: 10.1080/03007995.2018.1439829. 
      Epub 2018 Mar 12.