PMID- 29429538
OWN - NLM
STAT- MEDLINE
DCOM- 20191004
LR  - 20191210
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 47
DP  - 2018 Mar
TI  - Dietary non-enzymatic antioxidant capacity and DNA damage in a working 
      population.
PG  - 63-68
LID - S0899-9007(17)30221-6 [pii]
LID - 10.1016/j.nut.2017.10.004 [doi]
AB  - OBJECTIVE: The aim of this study was to investigate the potential links between 
      dietary non-enzymatic antioxidant capacity (NEAC) in overall diet and separately 
      from foods and beverages and markers of DNA damage. METHODS: The participants 
      were 513 employees, 20 to 65 y of age. Urinary levels of 8-hydroxydeoxyguanosine 
      (8-OHdG) and 7-methylguanine (m(7) Gua) were measured using column-switching 
      high-performance liquid chromatography. Dietary NEAC was determined from 
      databases of NEAC measurements obtained by different assays: ferric 
      reducing-antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and 
      total radical-trapping antioxidant parameter (TRAP). Dietary NEAC for each 
      participant was calculated by multiplying the estimated NEAC values with the 
      consumed amount and summing up those values, which was ascertained by a validated 
      brief self-administered diet history questionnaire. Multiple-regression analyses 
      were performed to assess the associations between dietary NEAC and 8-OHdG and 
      m(7) Gua, with adjustment for potential confounders. RESULTS: No statistically 
      significant associations were found between overall dietary NEAC or NEAC from 
      either foods or beverages and urinary 8-OHdG levels, after adjustment for 
      potential confounders (overall: FRAP, P(trend) = 0.40; ORAC, P = 0.27; TRAP, 
      P = 0.45). Likewise, no association was found between overall dietary NEAC and 
      m(7) Gua levels (FRAP, P(trend) = 0.30; ORAC, P = 0.65; TRAP, P = 0.41). However, 
      we did identify significant inverse association between NEAC from foods, as 
      estimated by TRAP, and m(7) Gua levels (P(trend) = 0.049). CONCLUSION: Overall, 
      dietary NEAC was not associated with 8-OHdG or m(7) Gua levels. In contrast, 
      dietary NEAC from foods but not beverages may be inversely associated with DNA 
      damage caused by methylation.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Kashino, Ikuko
AU  - Kashino I
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan. Electronic 
      address: Ikukokashino@gmail.com.
FAU - Li, Yun-Shan
AU  - Li YS
AD  - Department of Environmental Oncology, Institute of Industrial Ecological 
      Sciences, University of Occupational and Environmental Health, Fukuoka, Japan.
FAU - Kawai, Kazuaki
AU  - Kawai K
AD  - Department of Environmental Oncology, Institute of Industrial Ecological 
      Sciences, University of Occupational and Environmental Health, Fukuoka, Japan.
FAU - Nanri, Akiko
AU  - Nanri A
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
FAU - Miki, Takako
AU  - Miki T
AD  - Department of Mental Health, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Akter, Shamima
AU  - Akter S
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
FAU - Kobayashi, Satomi
AU  - Kobayashi S
AD  - Department of Social and Preventive Epidemiology, Graduate School of Medicine, 
      The University of Tokyo, Tokyo, Japan.
FAU - Kasai, Hiroshi
AU  - Kasai H
AD  - Department of Environmental Oncology, Institute of Industrial Ecological 
      Sciences, University of Occupational and Environmental Health, Fukuoka, Japan.
FAU - Mizoue, Tetsuya
AU  - Mizoue T
AD  - Department of Epidemiology and Prevention, Center for Clinical Sciences, National 
      Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180104
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Antioxidants)
RN  - 5Z93L87A1R (Guanine)
RN  - 661J4K04NB (7-methylguanine)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Adult
MH  - Aged
MH  - Antioxidants/*analysis
MH  - *DNA Damage
MH  - Deoxyguanosine/analogs & derivatives/urine
MH  - Diet/*statistics & numerical data
MH  - Female
MH  - Guanine/analogs & derivatives/urine
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Radical Absorbance Capacity
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Antioxidant
OT  - Asia
OT  - Cancer
OT  - Diet
OT  - Epidemiology
OT  - NEAC
OT  - TAC
EDAT- 2018/02/13 06:00
MHDA- 2019/10/08 06:00
CRDT- 2018/02/13 06:00
PHST- 2017/06/15 00:00 [received]
PHST- 2017/09/21 00:00 [revised]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2018/02/13 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
AID - S0899-9007(17)30221-6 [pii]
AID - 10.1016/j.nut.2017.10.004 [doi]
PST - ppublish
SO  - Nutrition. 2018 Mar;47:63-68. doi: 10.1016/j.nut.2017.10.004. Epub 2018 Jan 4.