PMID- 29429554
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20180420
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 517
DP  - 2018 Apr
TI  - Identification of small non-coding RNA classes expressed in swine whole blood 
      during HP-PRRSV infection.
PG  - 56-61
LID - S0042-6822(18)30033-3 [pii]
LID - 10.1016/j.virol.2018.01.027 [doi]
AB  - It has been established that reduced susceptibility to porcine reproductive and 
      respiratory syndrome virus (PRRSV) has a genetic component. This genetic 
      component may take the form of small non-coding RNAs (sncRNA), which are 
      molecules that function as regulators of gene expression. Various sncRNAs have 
      emerged as having an important role in the immune system in humans. The study 
      uses transcriptomic read counts to profile the type and quantity of both well and 
      lesser characterized sncRNAs, such as microRNAs and small nucleolar RNAs to 
      identify and quantify the classes of sncRNA expressed in whole blood between 
      healthy and highly pathogenic PRRSV-infected pigs. Our results returned evidence 
      on nine classes of sncRNA, four of which were consistently statistically 
      significantly different based on Fisher's Exact Test, that can be detected and 
      possibly interrogated for their effect on host dysregulation during PRRSV 
      infections.
CI  - Published by Elsevier Inc.
FAU - Fleming, Damarius S
AU  - Fleming DS
AD  - ORAU/ORISE, Oak Ridge, TN, USA; Virus and Prion Diseases of Livestock Research 
      Unit, National Animal Disease Center, USDA, Agricultural Research Service, P.O. 
      Box 70, Ames, IA 50010-0070, USA.
FAU - Miller, Laura C
AU  - Miller LC
AD  - Virus and Prion Diseases of Livestock Research Unit, National Animal Disease 
      Center, USDA, Agricultural Research Service, P.O. Box 70, Ames, IA 50010-0070, 
      USA. Electronic address: laura.miller@ars.usda.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180221
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (RNA, Small Untranslated)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Viral/physiology
MH  - Porcine Reproductive and Respiratory Syndrome/blood/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - RNA, Small Untranslated/*blood
MH  - RNA, Viral/*genetics
MH  - Swine/*blood
OTO - NOTNLM
OT  - Arteriviridae
OT  - Epigenetic
OT  - Non-coding RNA
OT  - PRRSV
OT  - Pig
EDAT- 2018/02/13 06:00
MHDA- 2018/04/21 06:00
CRDT- 2018/02/13 06:00
PHST- 2018/01/02 00:00 [received]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PHST- 2018/02/13 06:00 [entrez]
AID - S0042-6822(18)30033-3 [pii]
AID - 10.1016/j.virol.2018.01.027 [doi]
PST - ppublish
SO  - Virology. 2018 Apr;517:56-61. doi: 10.1016/j.virol.2018.01.027. Epub 2018 Feb 21.